Distinct microbial and immune niches of the human colon.
Journal
Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
10
05
2019
accepted:
15
01
2020
pubmed:
19
2
2020
medline:
21
4
2020
entrez:
19
2
2020
Statut:
ppublish
Résumé
Gastrointestinal microbiota and immune cells interact closely and display regional specificity; however, little is known about how these communities differ with location. Here, we simultaneously assess microbiota and single immune cells across the healthy, adult human colon, with paired characterization of immune cells in the mesenteric lymph nodes, to delineate colonic immune niches at steady state. We describe distinct helper T cell activation and migration profiles along the colon and characterize the transcriptional adaptation trajectory of regulatory T cells between lymphoid tissue and colon. Finally, we show increasing B cell accumulation, clonal expansion and mutational frequency from the cecum to the sigmoid colon and link this to the increasing number of reactive bacterial species.
Identifiants
pubmed: 32066951
doi: 10.1038/s41590-020-0602-z
pii: 10.1038/s41590-020-0602-z
pmc: PMC7212050
mid: EMS85484
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
343-353Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 213555
Pays : United Kingdom
Organisme : European Research Council
ID : 646794
Pays : International
Organisme : Medical Research Council
ID : MR/S035842/1
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
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