4'-Fluorinated RNA: Synthesis, Structure, and Applications as a Sensitive

Fluorine / chemistry Halogenation Molecular Probes / chemical synthesis Nuclear Magnetic Resonance, Biomolecular Nucleic Acid Conformation RNA / chemistry Ribonucleases / chemistry Uridine / analogs & derivatives

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
11 03 2020
Historique:
pubmed: 19 2 2020
medline: 14 5 2021
entrez: 19 2 2020
Statut: ppublish

Résumé

Fluorinated RNA molecules, particularly 2'-F RNA, have found a wide range of applications in RNA therapeutics, RNA aptamers, and ribozymes and as

Identifiants

DOI: 10.1021/jacs.9b13207 PMID: 32067454
pubmed: 32067454
doi: 10.1021/jacs.9b13207
doi:

Substances chimiques

Molecular Probes 0
Fluorine 284SYP0193
RNA 63231-63-0
Ribonucleases EC 3.1.-
Uridine WHI7HQ7H85

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4739-4748

Auteurs

Qiang Li (Q)

State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry, Nankai University, Tianjin 300071, China.

Jialiang Chen (J)

State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry, Nankai University, Tianjin 300071, China.

Marko Trajkovski (M)

Slovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, Ljubljana, Slovenia.
University of Ljubljana, Faculty of Chemistry and Chemical Technology, Ljubljana, EN-FIST Centre of Excellence, Ljubljana, Slovenia.

Yifei Zhou (Y)

State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry, Nankai University, Tianjin 300071, China.

Chaochao Fan (C)

State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry, Nankai University, Tianjin 300071, China.

Kuan Lu (K)

State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry, Nankai University, Tianjin 300071, China.

Pingping Tang (P)

State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry, Nankai University, Tianjin 300071, China.
ORCID: 0000-0002-8296-5695

Xuncheng Su (X)

State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry, Nankai University, Tianjin 300071, China.
ORCID: 0000-0003-3051-0047

Janez Plavec (J)

Slovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, Ljubljana, Slovenia.
University of Ljubljana, Faculty of Chemistry and Chemical Technology, Ljubljana, EN-FIST Centre of Excellence, Ljubljana, Slovenia.
ORCID: 0000-0003-1570-8602

Zhen Xi (Z)

State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry, Nankai University, Tianjin 300071, China.
ORCID: 0000-0002-3332-5413

Chuanzheng Zhou (C)

State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry, Nankai University, Tianjin 300071, China.
ORCID: 0000-0002-0811-7794

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Halogènes › Fluor › 4'-Fluorinated RNA: Synthesis, Structure, and...
questionsmedicales.fr › Métabolisme › Halogénation › 4'-Fluorinated RNA: Synthesis, Structure, and...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Sondes moléculaires › 4'-Fluorinated RNA: Synthesis, Structure, and...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Résonance magnétique nucléaire biomoléculaire › 4'-Fluorinated RNA: Synthesis, Structure, and...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › 4'-Fluorinated RNA: Synthesis, Structure, and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › 4'-Fluorinated RNA: Synthesis, Structure, and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Ribonucléases › 4'-Fluorinated RNA: Synthesis, Structure, and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Uridine › 4'-Fluorinated RNA: Synthesis, Structure, and...