A cell atlas of human thymic development defines T cell repertoire formation.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
21 02 2020
21 02 2020
Historique:
received:
08
06
2019
accepted:
16
01
2020
entrez:
22
2
2020
pubmed:
23
2
2020
medline:
17
4
2020
Statut:
ppublish
Résumé
The thymus provides a nurturing environment for the differentiation and selection of T cells, a process orchestrated by their interaction with multiple thymic cell types. We used single-cell RNA sequencing to create a cell census of the human thymus across the life span and to reconstruct T cell differentiation trajectories and T cell receptor (TCR) recombination kinetics. Using this approach, we identified and located in situ CD8αα
Identifiants
pubmed: 32079746
pii: 367/6480/eaay3224
doi: 10.1126/science.aay3224
pmc: PMC7611066
mid: EMS127082
pii:
doi:
Substances chimiques
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MC_PC_17230
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S035842/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_12009
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 221052
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17180
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R006237/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : European Research Council
ID : 646794
Pays : International
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Références
Trends Immunol. 2009 Jul;30(7):366-73
pubmed: 19540807
Cell Rep. 2017 Jun 6;19(10):2157-2173
pubmed: 28591585
Proc Natl Acad Sci U S A. 1994 May 24;91(11):4668-72
pubmed: 7910962
Nat Rev Immunol. 2011 May 27;11(7):489-95
pubmed: 21617694
Nature. 2019 Oct;574(7778):365-371
pubmed: 31597962
J Exp Med. 1993 Jan 1;177(1):19-33
pubmed: 8418199
Cell. 2018 Nov 29;175(6):1701-1715.e16
pubmed: 30449622
J Immunol. 2014 May 1;192(9):4017-23
pubmed: 24748636
J Exp Med. 2005 Jun 6;201(11):1715-23
pubmed: 15928199
J Exp Med. 2007 Jun 11;204(6):1267-72
pubmed: 17502664
J Immunol. 1993 Dec 1;151(11):6110-22
pubmed: 8245454
Nat Commun. 2019 Jun 3;10(1):2395
pubmed: 31160568
Sci Immunol. 2017 Feb 24;2(8):
pubmed: 28783686
Immune Netw. 2015 Jun;15(3):111-20
pubmed: 26140042
Nature. 2018 Nov;563(7731):347-353
pubmed: 30429548
Trends Immunol. 2007 Apr;28(4):169-75
pubmed: 17336158
Front Immunol. 2019 Jan 14;9:2902
pubmed: 30692988
Front Immunol. 2011 Aug 30;2:36
pubmed: 22566826
Nat Immunol. 2007 Apr;8(4):378-87
pubmed: 17334367
Nat Immunol. 2017 Jul;18(7):771-779
pubmed: 28530714
Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3206-15
pubmed: 23918392
Nature. 2018 Jul;559(7715):622-626
pubmed: 30022162
J Exp Med. 2011 Feb 14;208(2):383-94
pubmed: 21300913
Nature. 2005 Aug 25;436(7054):1181-5
pubmed: 16121185
Immunity. 2018 Jun 19;48(6):1258-1270.e6
pubmed: 29884461
Science. 2017 Apr 21;356(6335):
pubmed: 28428369
J Immunol. 2004 Mar 1;172(5):2731-8
pubmed: 14978070
Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8373-8
pubmed: 26056289
J Exp Med. 2017 Nov 6;214(11):3183-3195
pubmed: 28830910
Nat Rev Immunol. 2004 Feb;4(2):123-32
pubmed: 15040585
Blood. 2011 Apr 28;117(17):4449-59
pubmed: 21372153
J Immunol. 2012 May 15;188(10):4801-9
pubmed: 22504647
Exp Cell Res. 2013 May 15;319(9):1306-16
pubmed: 23422037
Development. 2018 Aug 13;145(16):
pubmed: 30042180
J Immunol. 2012 Dec 15;189(12):5519-26
pubmed: 23152561
Curr Opin Immunol. 2011 Apr;23(2):220-7
pubmed: 21257299
J Exp Med. 1997 May 5;185(9):1549-56
pubmed: 9151892
Front Immunol. 2015 Jul 20;6:365
pubmed: 26257733
Immunity. 2019 Nov 19;51(5):930-948.e6
pubmed: 31604687
Development. 2013 May;140(9):2015-26
pubmed: 23571219
Semin Immunol. 2005 Aug;17(4):304-12
pubmed: 15946853
Annu Rev Immunol. 2012;30:95-114
pubmed: 22149933
Front Immunol. 2015 Aug 07;6:398
pubmed: 26300884
Trends Immunol. 2019 Apr;40(4):279-291
pubmed: 30803714
Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1883-1888
pubmed: 29432166
Nat Immunol. 2019 Feb;20(2):195-205
pubmed: 30643267
PLoS One. 2015 Oct 30;10(10):e0140815
pubmed: 26517366
Int Rev Immunol. 1990;6(2-3):187-96
pubmed: 2152502
Trends Immunol. 2006 May;27(5):215-21
pubmed: 16580260
Genome Res. 2011 May;21(5):790-7
pubmed: 21349924
Arch Immunol Ther Exp (Warsz). 1998;46(4):253-7
pubmed: 9779292
Blood. 2007 Feb 1;109(3):954-60
pubmed: 17008543
Cell Adh Migr. 2010 Jul-Sep;4(3):382-90
pubmed: 20418658
J Immunol. 2001 Aug 15;167(4):1954-61
pubmed: 11489975
Bioinformatics. 2020 Feb 1;36(3):964-965
pubmed: 31400197
Sci Rep. 2015 Oct 08;5:14871
pubmed: 26445893
Immunity. 2018 Feb 20;48(2):202-213
pubmed: 29466753
J Neuroimmunol. 2004 Mar;148(1-2):97-105
pubmed: 14975590
Nature. 2018 Jul;559(7715):627-631
pubmed: 30022164
J Exp Med. 2013 Apr 8;210(4):683-97
pubmed: 23530123
Sci Immunol. 2018 Jan 19;3(19):
pubmed: 29352091
J Immunol. 2000 Sep 15;165(6):3094-8
pubmed: 10975821
Development. 2011 Sep;138(18):3865-78
pubmed: 21862553
J Immunol. 2010 Nov 15;185(10):6096-104
pubmed: 20956340
Trends Immunol. 2012 Jun;33(6):256-63
pubmed: 22591984