Plasma Levels of the Bioactive Sphingolipid Metabolite S1P in Adult Cystic Fibrosis Patients: Potential Target for Immunonutrition?
cystic fibrosis
high density lipoproteins
immunonutrition
intestine
sphingolipids
sphingosine-1-phosphate
ΔF508 mutation
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
14 Mar 2020
14 Mar 2020
Historique:
received:
17
01
2020
revised:
05
03
2020
accepted:
11
03
2020
entrez:
19
3
2020
pubmed:
19
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Recent research has linked sphingolipid (SL) metabolism with cystic fibrosis transmembrane conductance regulator (CFTR) activity, affecting bioactive lipid mediator sphingosine-1-phosphate (S1P). We hypothesize that loss of CFTR function in cystic fibrosis (CF) patients influenced plasma S1P levels. Total and unbound plasma S1P levels were measured in 20 lung-transplanted adult CF patients and 20 healthy controls by mass spectrometry and enzyme-linked immunosorbent assay (ELISA). S1P levels were correlated with CFTR genotype, routine laboratory parameters, lung function and pathogen colonization, and clinical symptoms. Compared to controls, CF patients showed lower unbound plasma S1P, whereas total S1P levels did not differ. A positive correlation of total and unbound S1P levels was found in healthy controls, but not in CF patients. Higher unbound S1P levels were measured in ΔF508-homozygous compared to ΔF508-heterozygous CF patients (
Identifiants
pubmed: 32183316
pii: nu12030765
doi: 10.3390/nu12030765
pmc: PMC7146441
pii:
doi:
Substances chimiques
CFTR protein, human
0
Lysophospholipids
0
Cystic Fibrosis Transmembrane Conductance Regulator
126880-72-6
sphingosine 1-phosphate
26993-30-6
Sphingosine
NGZ37HRE42
Types de publication
Clinical Trial
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Austrian Science Fund
ID : KLI 284
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