Anti-inflammatory effect of photodynamic therapy using guaiazulene and red lasers on peripheral blood mononuclear cells.

Azulenes Lasers Leukocytes, Mononuclear Photochemotherapy / methods Photosensitizing Agents / pharmacology Sesquiterpenes, Guaiane
Electron spin resonance spectrometer Fluorescence probe Guaiazulene PGE(2) Photodynamic therapy RANTES Singlet oxygen

Journal

Photodiagnosis and photodynamic therapy
ISSN: 1873-1597
Titre abrégé: Photodiagnosis Photodyn Ther
Pays: Netherlands
ID NLM: 101226123

Informations de publication

Date de publication:
Sep 2020
Historique:
received: 30 10 2019
revised: 18 02 2020
accepted: 16 03 2020
pubmed: 23 3 2020
medline: 15 5 2021
entrez: 23 3 2020
Statut: ppublish

Résumé

Photodynamic therapy improves oral mucositis treatment. The reactive oxygen species (ROS) generated from this reaction could contribute to an anti-inflammatory effect by suppressing inflammatory cells. To evaluate the anti-inflammatory effect of photodynamic therapy using guaiazulene and a red laser in peripheral blood mononuclear cells (PBMCs). Guaiazulene solutions (1, 2, 5, 25, 35, and 100 μM in 99.8 % methanol) were irradiated with red laser light (625 nm, 146.2 mW/cm Guaiazulene solutions between 2 and 5 μM exposed to red laser light at 4-8 J/cm Photodynamic activation of guaiazulene generated singlet oxygen and suppressed inflammatory markers in PBMCs.

Identifiants

DOI: 10.1016/j.pdpdt.2020.101747 PMID: 32200021
pubmed: 32200021
pii: S1572-1000(20)30100-9
doi: 10.1016/j.pdpdt.2020.101747
pii:
doi:

Substances chimiques

Azulenes 0
Photosensitizing Agents 0
Sesquiterpenes, Guaiane 0
guaiazulene 2OZ1K9JKQC

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

101747

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Ampika Phutim-Mangkhalthon (A)

Division of Paediatric Dentistry, Department of Preventive Dentistry, Faculty of Dentistry, Khon Kaen University, 40002, Thailand. Electronic address: ampika.mang@kkumail.com.

Aroon Teerakapong (A)

Division of Periodontology, Department of Oral Biomedical Sciences, Faculty of Dentistry, Khon Kaen University, 40002, Thailand; Lasers in Dentistry Research Group, Khon Kaen University, Thailand.

Patcharaporn Tippayawat (P)

Department of Clinical Chemistry, Faculty of Associated Medical Sciences, Khon Kaen University, 40002, Thailand. Electronic address: patchatip@kku.ac.th.

Noppawan Phumala Morales (NP)

Department of Pharmacology, Faculty of Sciences, Mahidol University, Bangkok, 10400, Thailand. Electronic address: noppawan.phu@mahidol.ac.th.

Supawich Morkmued (S)

Division of Paediatric Dentistry, Department of Preventive Dentistry, Faculty of Dentistry, Khon Kaen University, 40002, Thailand. Electronic address: supamo@kku.ac.th.

Subin Puasiri (S)

Department of Dental Public Health, Faculty of Dentistry, Khon Kaen University, 40002, Thailand. Electronic address: subin@kku.ac.th.

Aroonsri Priprem (A)

Melatonin Research Group and Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Khon Kaen University, 40002, Thailand. Electronic address: aroonsri@kku.ac.th.

Teerasak Damrongrungruang (T)

Division of Oral Diagnosis, Department of Oral Biomedical Science, Faculty of Dentistry, Khon Kaen University, 40002, Thailand; Lasers in Dentistry Research Group, Khon Kaen University, Thailand. Electronic address: dteera@kku.ac.th.

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Classifications MeSH

questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Azulènes › Anti-inflammatory effect of photodynamic...
questionsmedicales.fr › Équipement et fournitures › Équipement et fournitures pour les applications des radiations › Lasers › Anti-inflammatory effect of photodynamic...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Anti-inflammatory effect of photodynamic...
questionsmedicales.fr › Thérapeutique › Photothérapie › Photothérapie dynamique › Anti-inflammatory effect of photodynamic...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Radiosensibilisants › Photosensibilisants › Anti-inflammatory effect of photodynamic...
questionsmedicales.fr › Composés polycycliques › Sesquiterpènes polycycliques › Sesquiterpènes de type eudesmane › Sesquiterpènes de type guaïane › Anti-inflammatory effect of photodynamic...