The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future.
Journal
Cell stem cell
ISSN: 1875-9777
Titre abrégé: Cell Stem Cell
Pays: United States
ID NLM: 101311472
Informations de publication
Date de publication:
02 04 2020
02 04 2020
Historique:
entrez:
4
4
2020
pubmed:
4
4
2020
medline:
28
4
2021
Statut:
ppublish
Résumé
The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex multi-cellular organ that intimately links with the cardiovascular system to accomplish gas exchange. In this review and as members of the NIH/NHLBI-supported Progenitor Cell Translational Consortium, we discuss key aspects of lung repair and regeneration. We focus on the cellular compositions within functional niches, cell-cell signaling in homeostatic health, the responses to injury, and new methods to study lung repair and regeneration. We also provide future directions for an improved understanding of the cell biology of the respiratory system, as well as new therapeutic avenues.
Identifiants
pubmed: 32243808
pii: S1934-5909(20)30101-6
doi: 10.1016/j.stem.2020.03.009
pmc: PMC7128675
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
482-502Subventions
Organisme : NHLBI NIH HHS
ID : T32 HL007586
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL134745
Pays : United States
Organisme : NHLBI NIH HHS
ID : F32 HL143931
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL134760
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120046
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB027062
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL134766
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142727
Pays : United States
Organisme : NHLBI NIH HHS
ID : F32 HL149263
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007035
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL140178
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES013508
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
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