Cytotoxic Mechanism of Excess Polyamines Functions through Translational Repression of Specific Proteins Encoded by Polyamine Modulon.

Acetyltransferases / genetics Codon, Initiator Escherichia coli / genetics Escherichia coli Proteins / genetics Gene Expression Regulation, Bacterial / drug effects Microbial Viability / drug effects Polyamines / metabolism Protein Biosynthesis / drug effects Protein Processing, Post-Translational / drug effects RNA, Messenger Ribosomes / metabolism Spermidine / metabolism Transcription Factors / metabolism Trimebutine / metabolism
cell growth cell viability cytotoxicity polyamine modulon polyamines spermidine

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
31 Mar 2020
Historique:
received: 10 03 2020
revised: 28 03 2020
accepted: 29 03 2020
entrez: 5 4 2020
pubmed: 5 4 2020
medline: 5 1 2021
Statut: epublish

Résumé

Excessive accumulation of polyamines causes cytotoxicity, including inhibition of cell growth and a decrease in viability. We investigated the mechanism of cytotoxicity caused by spermidine accumulation under various conditions using an

Identifiants

DOI: 10.3390/ijms21072406 PMID: 32244348 PMC: PMC7177335
pubmed: 32244348
pii: ijms21072406
doi: 10.3390/ijms21072406
pmc: PMC7177335
pii:
doi:

Substances chimiques

Codon, Initiator 0
Escherichia coli Proteins 0
Polyamines 0
RNA, Messenger 0
Transcription Factors 0
Acetyltransferases EC 2.3.1.-
diamine N-acetyltransferase EC 2.3.1.57
Trimebutine QZ1OJ92E5R
Spermidine U87FK77H25

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Références

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Auteurs

Akihiko Sakamoto (A)

Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba 288-0025, Japan.

Junpei Sahara (J)

Faculty of Advanced Engineering, Chiba Institute of Technology, Chiba 275-0016, Japan.

Gota Kawai (G)

Faculty of Advanced Engineering, Chiba Institute of Technology, Chiba 275-0016, Japan.
ORCID: 0000-0003-1480-2840

Kaneyoshi Yamamoto (K)

Department of Frontier Bioscience, Hosei University, Tokyo 184-8584, Japan.
ORCID: 0000-0003-0696-8939

Akira Ishihama (A)

Department of Frontier Bioscience, Hosei University, Tokyo 184-8584, Japan.
ORCID: 0000-0002-6339-9042

Takeshi Uemura (T)

Amine Pharma Research Institute, Innovation Plaza at Chiba University, Chiba 260-0856, Japan.
Graduate School of Pharmaceutical Science, Chiba University, Chiba 260-0856, Japan.

Kazuei Igarashi (K)

Amine Pharma Research Institute, Innovation Plaza at Chiba University, Chiba 260-0856, Japan.
Graduate School of Pharmaceutical Science, Chiba University, Chiba 260-0856, Japan.

Keiko Kashiwagi (K)

Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba 288-0025, Japan.

Yusuke Terui (Y)

Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba 288-0025, Japan.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › Acetyltransferases › Cytotoxic Mechanism of Excess Polyamines...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Codon › Codon d'initiation › Cytotoxic Mechanism of Excess Polyamines...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Cytotoxic Mechanism of Excess Polyamines...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Protéines Escherichia coli › Cytotoxic Mechanism of Excess Polyamines...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes bactériens › Cytotoxic Mechanism of Excess Polyamines...
questionsmedicales.fr › Phénomènes microbiologiques › Viabilité microbienne › Cytotoxic Mechanism of Excess Polyamines...
questionsmedicales.fr › Composés chimiques organiques › Amines › Polyamines › Cytotoxic Mechanism of Excess Polyamines...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Biosynthèse des protéines › Cytotoxic Mechanism of Excess Polyamines...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Cytotoxic Mechanism of Excess Polyamines...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Cytotoxic Mechanism of Excess Polyamines...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Ribosomes › Cytotoxic Mechanism of Excess Polyamines...
questionsmedicales.fr › Composés chimiques organiques › Amines › Polyamines › Spermidine › Cytotoxic Mechanism of Excess Polyamines...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Cytotoxic Mechanism of Excess Polyamines...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Éthers phényliques › Éthers d'hydroxybenzoate › Trimébutine › Cytotoxic Mechanism of Excess Polyamines...