Neuro-Immune Circuits Regulate Immune Responses in Tissues and Organ Homeostasis.
Animals
Arthritis, Rheumatoid
/ immunology
Autoimmune Diseases
/ immunology
Autonomic Nervous System
/ physiology
Enteric Nervous System
/ physiology
Gastrointestinal Microbiome
Homeostasis
/ immunology
Humans
Hypothalamo-Hypophyseal System
/ physiology
Ileus
/ immunology
Immunity
/ immunology
Immunity, Innate
Inflammatory Bowel Diseases
/ immunology
Lymphocytes
/ immunology
Neuroimmunomodulation
/ drug effects
Neurons
/ physiology
Neuropeptides
/ immunology
Neurosecretory Systems
/ physiology
Neurotransmitter Agents
/ agonists
Postoperative Complications
/ immunology
Receptors, Neurotransmitter
/ immunology
Sepsis
/ immunology
Symbiosis
Vagus Nerve Stimulation
autonomous nervous system
chronic inflammatory diseases
enteric nervous system (ENS)
neuro-immune interactions
tissue homeostasis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
11
2019
accepted:
07
02
2020
entrez:
9
4
2020
pubmed:
9
4
2020
medline:
9
3
2021
Statut:
epublish
Résumé
The dense innervation of the gastro-intestinal tract with neuronal networks, which are in close proximity to immune cells, implies a pivotal role of neurons in modulating immune functions. Neurons have the ability to directly sense danger signals, adapt immune effector functions and integrate these signals to maintain tissue integrity and host defense strategies. The expression pattern of a large set of immune cells in the intestine characterized by receptors for neurotransmitters and neuropeptides suggest a tight neuronal hierarchical control of immune functions in order to systemically control immune reactions. Compelling evidence implies that targeting neuro-immune interactions is a promising strategy to dampen immune responses in autoimmune diseases such as inflammatory bowel diseases or rheumatoid arthritis. In fact, electric stimulation of vagal fibers has been shown to be an extremely effective treatment strategy against overwhelming immune reactions, even after exhausted conventional treatment strategies. Such findings argue that the nervous system is underestimated coordinator of immune reactions and underline the importance of neuro-immune crosstalk for body homeostasis. Herein, we review neuro-immune interactions with a special focus on disease pathogenesis throughout the gastro-intestinal tract.
Identifiants
pubmed: 32265899
doi: 10.3389/fimmu.2020.00308
pmc: PMC7099652
doi:
Substances chimiques
Neuropeptides
0
Neurotransmitter Agents
0
Receptors, Neurotransmitter
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
308Informations de copyright
Copyright © 2020 Jakob, Murugan and Klose.
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