Hispanic/Latino Patients with Gastric Adenocarcinoma Have Distinct Molecular Profiles Including a High Rate of Germline
Adenocarcinoma
/ blood
Adult
Aged
Aged, 80 and over
Animals
Antigens, CD
/ genetics
CHO Cells
Cadherins
/ genetics
Cricetulus
DNA Methylation
Female
Genetic Predisposition to Disease
Hispanic or Latino
/ genetics
Humans
Male
Middle Aged
Mutation
Promoter Regions, Genetic
Stomach Neoplasms
/ blood
Exome Sequencing
Young Adult
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
received:
17
09
2019
revised:
05
02
2020
accepted:
30
03
2020
pubmed:
10
4
2020
medline:
12
11
2020
entrez:
10
4
2020
Statut:
ppublish
Résumé
Hispanic/Latino patients have a higher incidence of gastric cancer and worse cancer-related outcomes compared with patients of other backgrounds. Whether there is a molecular basis for these disparities is unknown, as very few Hispanic/Latino patients have been included in previous studies. To determine the genomic landscape of gastric cancer in Hispanic/Latino patients, we performed whole-exome sequencing (WES) and RNA sequencing on tumor samples from 57 patients; germline analysis was conducted on 83 patients. The results were compared with data from Asian and White patients published by The Cancer Genome Atlas. Hispanic/Latino patients had a significantly larger proportion of genomically stable subtype tumors compared with Asian and White patients (65% vs. 21% vs. 20%,
Identifiants
pubmed: 32269045
pii: 0008-5472.CAN-19-2918
doi: 10.1158/0008-5472.CAN-19-2918
pmc: PMC7489496
mid: NIHMS1582581
doi:
Substances chimiques
Antigens, CD
0
CDH1 protein, human
0
Cadherins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2114-2124Subventions
Organisme : NCI NIH HHS
ID : K08 CA222611
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA142543
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK111588
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001105
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
Références
J Surg Oncol. 2012 Sep 1;106(3):346-52
pubmed: 22331676
Nature. 2014 Sep 11;513(7517):202-9
pubmed: 25079317
Cancer Cell. 2018 Oct 8;34(4):549-560.e9
pubmed: 30300578
Anticancer Res. 2006 Jul-Aug;26(4B):2909-14
pubmed: 16886612
Cell Rep. 2015 Jul 14;12(2):272-85
pubmed: 26146084
J Clin Oncol. 2016 Jan 1;34(1):91-101
pubmed: 26578615
Int J Surg Pathol. 2006 Jan;14(1):21-33
pubmed: 16501831
Clin Exp Med. 2013 May;13(2):149-57
pubmed: 22543498
Eur J Cancer. 2011 Mar;47(4):631-9
pubmed: 21106365
J Med Genet. 2015 Jun;52(6):361-74
pubmed: 25979631
Dig Dis Sci. 2015 Apr;60(4):984-95
pubmed: 25354832
Nat Med. 2015 May;21(5):449-56
pubmed: 25894828
J Med Genet. 2019 Dec;56(12):838-843
pubmed: 31296550
Nat Rev Genet. 2005 Apr;6(4):333-40
pubmed: 15803201
PLoS One. 2013 Oct 29;8(10):e77035
pubmed: 24204729
J Thorac Oncol. 2014 Feb;9(2):154-62
pubmed: 24419411
JAMA. 2010 May 5;303(17):1723-8
pubmed: 20442388
World J Gastroenterol. 2013 Feb 14;19(6):909-16
pubmed: 23431106
J Clin Oncol. 2005 May 1;23(13):3094-103
pubmed: 15860869
Oncogene. 2001 Mar 22;20(12):1525-8
pubmed: 11313896
J Med Genet. 2006 Nov;43(11):867-72
pubmed: 16801346
Microbiome. 2014 Sep 05;2:33
pubmed: 25225611
Cancer. 2008 Aug 1;113(3):461-9
pubmed: 18553367
JAMA Oncol. 2018 Nov 1;4(11):1553-1568
pubmed: 29860482
J Clin Oncol. 2015 Sep 1;33(25):2789-96
pubmed: 26195723
Nucleic Acids Res. 2016 Jan 4;44(D1):D862-8
pubmed: 26582918
Gastroenterology. 2017 Apr;152(5):983-986.e6
pubmed: 28024868
Gastric Cancer. 2016 Jan;19(1):116-27
pubmed: 25618371
Nat Med. 2018 Sep;24(9):1449-1458
pubmed: 30013197
Gastroenterology. 2009 Jun;136(7):2137-48
pubmed: 19269290
PLoS One. 2015 Sep 11;10(9):e0137657
pubmed: 26360582
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
JCO Precis Oncol. 2017;2017:
pubmed: 30211344
Cancer Res. 2013 Dec 15;73(24):7243-53
pubmed: 24177181
Genome Med. 2017 Oct 31;9(1):93
pubmed: 29089060
Cell. 2018 Apr 5;173(2):400-416.e11
pubmed: 29625055
JAMA Oncol. 2015 Apr;1(1):23-32
pubmed: 26182300
Cancer Epidemiol Biomarkers Prev. 2010 Apr;19(4):1074-82
pubmed: 20332279
JAMA Oncol. 2019 Sep 01;5(9):1325-1331
pubmed: 31246251
JCO Precis Oncol. 2017 Nov;1:1-12
pubmed: 35172483
Bioinformatics. 2014 Apr 1;30(7):1015-6
pubmed: 24371154
CA Cancer J Clin. 2015 Nov-Dec;65(6):457-80
pubmed: 26375877
JAMA Oncol. 2016 Aug 1;2(8):1070-4
pubmed: 27366979
Gastroenterology. 2017 Aug;153(2):536-549.e26
pubmed: 28522256
PLoS One. 2012;7(3):e33783
pubmed: 22470475
Nat Med. 2018 Jul;24(7):968-977
pubmed: 29808010
Clin Cancer Res. 2017 Aug 1;23(15):4441-4449
pubmed: 28747339
Nat Rev Cancer. 2015 Apr;15(4):248-54
pubmed: 25673085