Comprehensive analyses of 723 transcriptomes enhance genetic and biological interpretations for complex traits in cattle.
Journal
Genome research
ISSN: 1549-5469
Titre abrégé: Genome Res
Pays: United States
ID NLM: 9518021
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
22
03
2019
accepted:
01
05
2020
pubmed:
20
5
2020
medline:
13
7
2021
entrez:
20
5
2020
Statut:
ppublish
Résumé
By uniformly analyzing 723 RNA-seq data from 91 tissues and cell types, we built a comprehensive gene atlas and studied tissue specificity of genes in cattle. We demonstrated that tissue-specific genes significantly reflected the tissue-relevant biology, showing distinct promoter methylation and evolution patterns (e.g., brain-specific genes evolve slowest, whereas testis-specific genes evolve fastest). Through integrative analyses of those tissue-specific genes with large-scale genome-wide association studies, we detected relevant tissues/cell types and candidate genes for 45 economically important traits in cattle, including blood/immune system (e.g.,
Identifiants
pubmed: 32424068
pii: gr.250704.119
doi: 10.1101/gr.250704.119
pmc: PMC7263193
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
790-801Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/D/10002070
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/D/30002275
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P015514/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R025851/1
Pays : United Kingdom
Informations de copyright
© 2020 Fang et al.; Published by Cold Spring Harbor Laboratory Press.
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