Distribution of HLA allele frequencies in 82 Chinese individuals with coronavirus disease-2019 (COVID-19).
Alleles
Asian People
/ genetics
Betacoronavirus
COVID-19
China
/ epidemiology
Coronavirus Infections
/ genetics
Gene Frequency
Genotype
HLA Antigens
/ genetics
Haplotypes
High-Throughput Nucleotide Sequencing
Humans
Immune System
Models, Statistical
Pandemics
Pneumonia, Viral
/ genetics
Polymorphism, Genetic
SARS-CoV-2
HLA
Han population
allele frequency
coronavirus disease-2019
Journal
HLA
ISSN: 2059-2310
Titre abrégé: HLA
Pays: England
ID NLM: 101675570
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
29
04
2020
revised:
12
05
2020
accepted:
15
05
2020
pubmed:
20
5
2020
medline:
28
7
2020
entrez:
20
5
2020
Statut:
ppublish
Résumé
COVID-19 is a respiratory disease caused by a novel coronavirus and is currently a global pandemic. HLA variation is associated with COVID-19 because HLA plays a pivotal role in the immune response to pathogens. Here, 82 individuals with COVID-19 were genotyped for HLA-A, -B, -C, -DRB1, -DRB3/4/5, -DQA1, -DQB1, -DPA1, and -DPB1 loci using next-generation sequencing (NGS). Frequencies of the HLA-C*07:29, C*08:01G, B*15:27, B*40:06, DRB1*04:06, and DPB1*36:01 alleles were higher, while the frequencies of the DRB1*12:02 and DPB1*04:01 alleles were lower in COVID-19 patients than in the control population, with uncorrected statistical significance. Only HLA-C*07:29 and B*15:27 were significant when the corrected P-value was considered. These data suggested that some HLA alleles may be associated with the occurrence of COVID-19.
Identifiants
pubmed: 32424945
doi: 10.1111/tan.13941
pmc: PMC7276866
doi:
Substances chimiques
HLA Antigens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
194-196Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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