Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer.

Cancer-Associated Fibroblasts / immunology Cell Line, Tumor Datasets as Topic Drug Resistance, Neoplasm / immunology Humans Immune Checkpoint Inhibitors / pharmacology Neoplasms / drug therapy Primary Cell Culture RNA-Seq Single-Cell Analysis T-Lymphocytes, Regulatory / immunology Tumor Escape Tumor Microenvironment / immunology

Journal

Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693

Informations de publication

Date de publication:
09 2020
Historique:
received: 26 11 2019
revised: 26 03 2020
accepted: 15 05 2020
pubmed: 22 5 2020
medline: 30 11 2021
entrez: 22 5 2020
Statut: ppublish

Résumé

A subset of cancer-associated fibroblasts (FAP

Identifiants

DOI: 10.1158/2159-8290.CD-19-1384 PMID: 32434947
pubmed: 32434947
pii: 2159-8290.CD-19-1384
doi: 10.1158/2159-8290.CD-19-1384
doi:

Substances chimiques

Immune Checkpoint Inhibitors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1330-1351

Informations de copyright

©2020 American Association for Cancer Research.

Auteurs

Yann Kieffer (Y)

Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University, Paris, France.
Inserm, U830, Paris, France.
ORCID: 0000-0003-2722-3071

Hocine R Hocine (HR)

Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University, Paris, France.
Inserm, U830, Paris, France.
ORCID: 0000-0003-1144-9818

Géraldine Gentric (G)

Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University, Paris, France.
Inserm, U830, Paris, France.
ORCID: 0000-0002-7558-8705

Floriane Pelon (F)

Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University, Paris, France.
Inserm, U830, Paris, France.

Charles Bernard (C)

Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University, Paris, France.
Inserm, U830, Paris, France.
ORCID: 0000-0002-8354-5350

Brigitte Bourachot (B)

Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University, Paris, France.
Inserm, U830, Paris, France.

Sonia Lameiras (S)

ICGex Next-Generation Sequencing Platform, Institut Curie, SIRIC, Paris, France.

Luca Albergante (L)

Institut Curie, Inserm, U900, PSL Research University, Paris, France.
Mines ParisTech, CBIO-Centre for Computational Biology, Paris, France.
ORCID: 0000-0001-8151-6989

Claire Bonneau (C)

Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University, Paris, France.
Inserm, U830, Paris, France.
Department of Surgery, Institut Curie Hospital Group, Saint-Cloud, France.
ORCID: 0000-0001-6251-286X

Alice Guyard (A)

Department of Pathology Bichat Claude Bernard Hospital Group, Paris Diderot University, Paris, France.

Karin Tarte (K)

UMR U1236-MICMAC, Immunology and Cell Therapy Lab, Rennes University, Rennes, France.

Andrei Zinovyev (A)

Institut Curie, Inserm, U900, PSL Research University, Paris, France.
Mines ParisTech, CBIO-Centre for Computational Biology, Paris, France.
ORCID: 0000-0002-9517-7284

Sylvain Baulande (S)

ICGex Next-Generation Sequencing Platform, Institut Curie, SIRIC, Paris, France.
ORCID: 0000-0003-3104-1684

Gerard Zalcman (G)

Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University, Paris, France.
Inserm, U830, Paris, France.
Thoracic Oncology Department, CIC 1425-CLIP2, Bichat Claude Bernard Hospital Group, Paris Diderot University, Paris, France.

Anne Vincent-Salomon (A)

Department of Diagnostic and Theragnostic Medicine, Institut Curie Hospital Group, Paris, France.

Fatima Mechta-Grigoriou (F)

Institut Curie, Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, PSL Research University, Paris, France. fatima.mechta-grigoriou@curie.fr.
Inserm, U830, Paris, France.
ORCID: 0000-0002-3751-6989

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Fibroblastes associés au cancer › Single-Cell Analysis Reveals Fibroblast...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Single-Cell Analysis Reveals Fibroblast...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Jeux de données comme sujet › Single-Cell Analysis Reveals Fibroblast...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Single-Cell Analysis Reveals Fibroblast...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Single-Cell Analysis Reveals Fibroblast...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques immunologiques › Inhibiteurs de points de contrôle immunitaires › Single-Cell Analysis Reveals Fibroblast...
questionsmedicales.fr › Tumeurs › Single-Cell Analysis Reveals Fibroblast...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture cellulaire › Culture de cellules primaires › Single-Cell Analysis Reveals Fibroblast...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ARN › RNA-Seq › Single-Cell Analysis Reveals Fibroblast...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › Single-Cell Analysis Reveals Fibroblast...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Single-Cell Analysis Reveals Fibroblast...
questionsmedicales.fr › Phénomènes du système immunitaire › Échappement de la tumeur à la surveillance immunitaire › Single-Cell Analysis Reveals Fibroblast...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Single-Cell Analysis Reveals Fibroblast...