Phallac acids A and B, new sesquiterpenes from the fruiting bodies of Phallus luteus.
Journal
The Journal of antibiotics
ISSN: 1881-1469
Titre abrégé: J Antibiot (Tokyo)
Pays: England
ID NLM: 0151115
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
12
03
2020
accepted:
08
05
2020
pubmed:
31
5
2020
medline:
20
2
2021
entrez:
31
5
2020
Statut:
ppublish
Résumé
Phallus luteus (Phallaceae), previously known as Dictyophora indusiata, is an edible and medicinal mushroom. As part of a continuing project to discover structurally and/or biologically novel natural products from wild mushrooms, we aimed to perform a chemical investigation of the methanol extract of P. luteus combined with a liquid chromatography-mass spectrometry-guided analysis coupled to an in-house UV spectral library. Two new sesquiterpenes, phallac acids A (1) and B (2), were isolated and determined. The chemical structure of the new natural products was unambiguously determined using a combination of 1D and 2D NMR and high-resolution electrospray ionization mass spectrometry data. To our knowledge, this is the first study to report linear sesquiterpene carboxylic acids from P. luteus. The new compounds were evaluated for α-glucosidase inhibitory activities where phallac acid B (2) showed α-glucosidase inhibitory potential (IC
Identifiants
pubmed: 32472053
doi: 10.1038/s41429-020-0328-z
pii: 10.1038/s41429-020-0328-z
doi:
Substances chimiques
Glycoside Hydrolase Inhibitors
0
Sesquiterpenes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
729-732Références
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