Pathogenic Allodiploid Hybrids of Aspergillus Fungi.
Eurotiomycetes
allopolyploidy
ascomycota
aspergillosis
cryptic species
fungal pathogen evolution
hybridization
nonvertical evolution
pathogenicity
virulence
Journal
Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782
Informations de publication
Date de publication:
06 07 2020
06 07 2020
Historique:
received:
16
07
2019
revised:
25
02
2020
accepted:
24
04
2020
pubmed:
6
6
2020
medline:
10
8
2021
entrez:
6
6
2020
Statut:
ppublish
Résumé
Interspecific hybridization substantially alters genotypes and phenotypes and can give rise to new lineages. Hybrid isolates that differ from their parental species in infection-relevant traits have been observed in several human-pathogenic yeasts and plant-pathogenic filamentous fungi but have yet to be found in human-pathogenic filamentous fungi. We discovered 6 clinical isolates from patients with aspergillosis originally identified as Aspergillus nidulans (section Nidulantes) that are actually allodiploid hybrids formed by the fusion of Aspergillus spinulosporus with an unknown close relative of Aspergillus quadrilineatus, both in section Nidulantes. Evolutionary genomic analyses revealed that these isolates belong to Aspergillus latus, an allodiploid hybrid species. Characterization of diverse infection-relevant traits further showed that A. latus hybrid isolates are genomically and phenotypically heterogeneous but also differ from A. nidulans, A. spinulosporus, and A. quadrilineatus. These results suggest that allodiploid hybridization contributes to the genomic and phenotypic diversity of filamentous fungal pathogens of humans.
Identifiants
pubmed: 32502407
pii: S0960-9822(20)30587-X
doi: 10.1016/j.cub.2020.04.071
pmc: PMC7343619
mid: NIHMS1589981
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
2495-2507.e7Subventions
Organisme : NCCIH NIH HHS
ID : F31 AT010558
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA125066
Pays : United States
Organisme : NLM NIH HHS
ID : T15 LM007450
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
Références
Nature. 2005 Dec 22;438(7071):1105-15
pubmed: 16372000
PLoS Pathog. 2009 Jan;5(1):e1000283
pubmed: 19180236
PLoS Genet. 2008 Apr 11;4(4):e1000046
pubmed: 18404212
Genome Res. 2003 Sep;13(9):2178-89
pubmed: 12952885
Mycopathologia. 2014 Dec;178(5-6):427-33
pubmed: 24972670
Bioinformatics. 2014 Jan 1;30(1):31-7
pubmed: 23732276
CSH Protoc. 2008 Jun 01;2008:pdb.top39
pubmed: 21356855
Nat Rev Microbiol. 2017 Nov;15(11):661-674
pubmed: 28919635
Science. 2003 Aug 29;301(5637):1211-6
pubmed: 12907807
PLoS One. 2011;6(12):e29216
pubmed: 22216217
Semin Cell Dev Biol. 2019 May;89:34-46
pubmed: 29522807
Microbiol Resour Announc. 2019 Sep 19;8(38):
pubmed: 31537670
Yeast. 2018 Jan;35(1):5-20
pubmed: 28681409
Proc Natl Acad Sci U S A. 2007 May 15;104(20):8397-402
pubmed: 17494770
Stud Mycol. 2016 Jun;84:1-118
pubmed: 28050053
PLoS Pathog. 2015 Oct 22;11(10):e1005187
pubmed: 26492565
Antimicrob Agents Chemother. 2018 Dec 21;63(1):
pubmed: 30397071
PLoS One. 2011 Mar 24;6(3):e18260
pubmed: 21455321
Mol Biol Evol. 2013 Apr;30(4):772-80
pubmed: 23329690
Nucleic Acids Res. 2013 Jan;41(Database issue):D358-65
pubmed: 23180791
PLoS Biol. 2017 May 16;15(5):e2002128
pubmed: 28510588
Fungal Genet Biol. 2000 Oct;31(1):21-32
pubmed: 11118132
Sci Transl Med. 2012 Dec 19;4(165):165rv13
pubmed: 23253612
Bioinformatics. 2014 May 1;30(9):1312-3
pubmed: 24451623
Med Mycol. 2011 Apr;49 Suppl 1:S82-9
pubmed: 20662634
Genetics. 2017 Sep;207(1):327-346
pubmed: 28679543
mBio. 2019 Jul 9;10(4):
pubmed: 31289177
PLoS Pathog. 2020 Feb 27;16(2):e1008315
pubmed: 32106242
mBio. 2011 Sep 06;2(5):
pubmed: 21896680
Mol Biol Evol. 2007 Aug;24(8):1586-91
pubmed: 17483113
J Comput Biol. 2015 Jun;22(6):528-45
pubmed: 25734602
Syst Biol. 2002 Jun;51(3):492-508
pubmed: 12079646
Phytopathology. 2016 Feb;106(2):104-12
pubmed: 26824768
Eukaryot Cell. 2005 Mar;4(3):625-32
pubmed: 15755924
Bioinformatics. 2012 Feb 1;28(3):423-5
pubmed: 22155870
Nat Biotechnol. 2007 Feb;25(2):221-31
pubmed: 17259976
Genome Announc. 2015 Apr 16;3(2):
pubmed: 25883274
Genetica. 2007 Feb;129(2):149-65
pubmed: 16955330
Bioinformatics. 2003 Oct;19 Suppl 2:ii215-25
pubmed: 14534192
Blood. 2013 Mar 28;121(13):2385-92
pubmed: 23335372
Bioinformatics. 2015 Oct 1;31(19):3210-2
pubmed: 26059717
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W609-12
pubmed: 16845082
Nat Genet. 2016 Feb;48(2):201-5
pubmed: 26752267
Nature. 2003 Mar 27;422(6930):433-8
pubmed: 12660784
Evolution. 2005 Sep;59(9):1886-99
pubmed: 16261727
Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):388-93
pubmed: 9419385
Nature. 1997 Jun 12;387(6634):708-13
pubmed: 9192896
J Infect Dis. 2012 Oct 1;206(7):1128-37
pubmed: 22829648
J Gen Microbiol. 1984 Sep;130(9):2229-36
pubmed: 6389760
Int J Infect Dis. 2004 Mar;8(2):103-10
pubmed: 14732328
Drug Resist Updat. 2015 Jul-Aug;21-22:30-40
pubmed: 26282594
Nature. 2005 Dec 22;438(7071):1151-6
pubmed: 16372009
PLoS Genet. 2016 Nov 2;12(11):e1006404
pubmed: 27806045
J Mol Evol. 1994 Sep;39(3):306-14
pubmed: 7932792
Bioinformatics. 2008 Mar 15;24(6):878-9
pubmed: 18245128
Curr Opin Microbiol. 2016 Aug;32:7-13
pubmed: 27116367
mSphere. 2020 Apr 8;5(2):
pubmed: 32269156
Eukaryot Cell. 2007 Dec;6(12):2290-302
pubmed: 17921349
Mol Ecol. 2015 Apr;24(8):1889-909
pubmed: 25773520
J Comput Biol. 2012 May;19(5):455-77
pubmed: 22506599
Infect Dis Clin North Am. 2006 Sep;20(3):545-61, vi
pubmed: 16984868
G3 (Bethesda). 2016 Nov 8;6(11):3655-3662
pubmed: 27638685
Mol Gen Genet. 1979 Feb 26;170(2):213-8
pubmed: 372762
Microb Biotechnol. 2017 Mar;10(2):296-322
pubmed: 27273822
Nat Microbiol. 2019 Dec;4(12):2430-2441
pubmed: 31548684
Mol Biol Evol. 2018 Feb 1;35(2):518-522
pubmed: 29077904
J Microbiol. 2016 Mar;54(3):243-53
pubmed: 26920884
Mol Biol Evol. 2015 Jan;32(1):268-74
pubmed: 25371430
Bioinformatics. 2013 Apr 15;29(8):1072-5
pubmed: 23422339
Lancet Infect Dis. 2017 Dec;17(12):e383-e392
pubmed: 28774698
J Immunol. 2016 Feb 1;196(3):1272-83
pubmed: 26718340
Nature. 1952 Oct 25;170(4330):713-4
pubmed: 13002420
CSH Protoc. 2008 Dec 01;2008:pdb.prot5080
pubmed: 21356739
Bioinformatics. 2009 Aug 1;25(15):1972-3
pubmed: 19505945
Nucleic Acids Res. 2015 Jul 1;43(W1):W237-43
pubmed: 25948579
Genome Res. 2008 Oct;18(10):1610-23
pubmed: 18787083
mBio. 2017 Feb 21;8(1):
pubmed: 28223452
Trends Ecol Evol. 1996 Sep;11(9):367-72
pubmed: 21237881
mBio. 2016 Sep 20;7(5):
pubmed: 27651366
Genome Res. 2011 Jun;21(6):974-84
pubmed: 21324876
Mol Microbiol. 2010 Feb;75(4):910-23
pubmed: 20487287
Front Microbiol. 2019 Apr 24;10:854
pubmed: 31105662
Methods Mol Biol. 2012;845:99-118
pubmed: 22328370
Curr Opin Genet Dev. 2007 Dec;17(6):513-8
pubmed: 17933508
PLoS Biol. 2015 Aug 07;13(8):e1002221
pubmed: 26252643
Mol Biol Evol. 2006 Sep;23(9):1808-16
pubmed: 16809621
Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9903-8
pubmed: 15161969
Eukaryot Cell. 2015 Aug;14(8):728-44
pubmed: 25911225
Nat Immunol. 2014 Nov;15(11):1017-25
pubmed: 25217981
Genome Biol. 2017 Feb 14;18(1):28
pubmed: 28196534
J Evol Biol. 2013 Feb;26(2):229-46
pubmed: 23323997
PLoS Genet. 2015 Oct 30;11(10):e1005626
pubmed: 26517373
PLoS Biol. 2015 Aug 07;13(8):e1002220
pubmed: 26252497
Fungal Genet Biol. 2007 Jan;44(1):25-31
pubmed: 16879998
BMC Bioinformatics. 2009 Dec 15;10:421
pubmed: 20003500