LeishIF4E-1
Leishmania
NMR
Translation initiation
Journal
Biomolecular NMR assignments
ISSN: 1874-270X
Titre abrégé: Biomol NMR Assign
Pays: Netherlands
ID NLM: 101472371
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
29
04
2020
accepted:
02
06
2020
pubmed:
11
6
2020
medline:
1
9
2021
entrez:
11
6
2020
Statut:
ppublish
Résumé
Most of the translational control of gene expression in higher eukaryotes occurs during the initiation step of protein synthesis. While this process is well characterized in mammalian cells, it is less defined in parasites, including the ones that cause human Leishmaniasis. The Leishmania cap-binding isoform 1 (LeishIF4E-1) is the only isoform that binds the specific trypanosomatids-specific hypermethylated 5' cap, called cap-4, in the human stage of the parasite life cycle. We report here the extensive NMR resonance assignment of LeishIF4E-1 bound to a cap analog, m
Identifiants
pubmed: 32519295
doi: 10.1007/s12104-020-09958-3
pii: 10.1007/s12104-020-09958-3
pmc: PMC7462832
doi:
Substances chimiques
Eukaryotic Initiation Factor-4E
0
Nitrogen Isotopes
0
Nitrogen-15
0
Protozoan Proteins
0
RNA Cap Analogs
0
RNA Caps
0
7-methylguanosine triphosphate
45LQ9B0V54
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
259-263Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001102
Pays : United States
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