Transcriptomic responses of a New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae isolate to the combination of polymyxin B and chloramphenicol.

Anti-Bacterial Agents / pharmacology Bacterial Proteins Chloramphenicol / pharmacology Drug Combinations Drug Resistance, Multiple, Bacterial Drug Synergism Gene Expression Regulation, Bacterial Humans Klebsiella Infections / drug therapy Klebsiella pneumoniae / drug effects Metabolic Networks and Pathways Microbial Sensitivity Tests Polymyxin B / pharmacology RNA, Bacterial Sequence Analysis, RNA Transcriptome beta-Lactamases / genetics
Chloramphenicol Klebsiella pneumoniae New Delhi metallo-β-lactamase Polymyxin B Systems pharmacology Transcriptomics

Journal

International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860

Informations de publication

Date de publication:
Aug 2020
Historique:
received: 13 01 2020
revised: 08 06 2020
pubmed: 24 6 2020
medline: 20 5 2021
entrez: 24 6 2020
Statut: ppublish

Résumé

The combination of polymyxins and chloramphenicol possesses synergistic killing activity against New Delhi metallo-β-lactamase (NDM)-producing Klebsiella pneumoniae. This systems study examined the transcriptomic responses to the polymyxin/chloramphenicol combination in clinical NDM-producing K. pneumoniae isolate S01. Klebsiella pneumoniae S01 (initial inoculum ~10

Identifiants

DOI: 10.1016/j.ijantimicag.2020.106061 PMID: 32574791
pubmed: 32574791
pii: S0924-8579(20)30231-4
doi: 10.1016/j.ijantimicag.2020.106061
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Bacterial Proteins 0
Drug Combinations 0
RNA, Bacterial 0
Chloramphenicol 66974FR9Q1
beta-Lactamases EC 3.5.2.6
beta-lactamase NDM-1 EC 3.5.2.6
Polymyxin B J2VZ07J96K

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106061

Informations de copyright

Copyright © 2020 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

Auteurs

Nusaibah Abdul Rahim (N)

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia; Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia.

Soon-Ee Cheah (SE)

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia.

Matthew D Johnson (MD)

Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia.

Yan Zhu (Y)

Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia.

Heidi H Yu (HH)

Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia.

Hanna E Sidjabat (HE)

University of Queensland Centre for Clinical Research, Herston, Queensland, Australia.

Mark S Butler (MS)

Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.

Matthew A Cooper (MA)

Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.

Jing Fu (J)

Department of Mechanical and Aerospace Engineering, Faculty of Engineering, Monash University, Melbourne, Victoria, Australia.

David L Paterson (DL)

University of Queensland Centre for Clinical Research, Herston, Queensland, Australia; Pathology Queensland, Royal Brisbane and Women's Hospital Campus, Herston, Queensland, Australia.

Roger L Nation (RL)

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia.

John D Boyce (JD)

Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia.

Phillip J Bergen (PJ)

Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia; Centre for Medicine Use and Safety, Monash University, Melbourne, Victoria, Australia.

Tony Velkov (T)

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia; Department of Pharmacology & Therapeutics, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.

Jian Li (J)

Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia. Electronic address: Colistin.Polymyxin@gmail.com.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Transcriptomic responses of a New Delhi...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Transcriptomic responses of a New Delhi...
questionsmedicales.fr › Composés chimiques organiques › Composés nitrés › Nitrobenzènes › Chloramphénicol › Transcriptomic responses of a New Delhi...
questionsmedicales.fr › Préparations pharmaceutiques › Association médicamenteuse › Transcriptomic responses of a New Delhi...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Multirésistance aux médicaments › Multirésistance bactérienne aux médicaments › Transcriptomic responses of a New Delhi...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Interactions médicamenteuses › Synergie des médicaments › Transcriptomic responses of a New Delhi...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes bactériens › Transcriptomic responses of a New Delhi...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Transcriptomic responses of a New Delhi...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Enterobacteriaceae › Infections à Klebsiella › Transcriptomic responses of a New Delhi...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Klebsiella › Klebsiella pneumoniae › Transcriptomic responses of a New Delhi...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Transcriptomic responses of a New Delhi...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Transcriptomic responses of a New Delhi...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Peptides antimicrobiens cationiques › Polymyxines › Polymyxine B › Transcriptomic responses of a New Delhi...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN bactérien › Transcriptomic responses of a New Delhi...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ARN › Transcriptomic responses of a New Delhi...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Transcriptomic responses of a New Delhi...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › bêta-Lactamases › Transcriptomic responses of a New Delhi...