Exploring whole-genome duplicate gene retention with complex genetic interaction analysis.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
26 06 2020
26 06 2020
Historique:
received:
19
09
2019
accepted:
06
05
2020
entrez:
27
6
2020
pubmed:
27
6
2020
medline:
10
7
2020
Statut:
ppublish
Résumé
Whole-genome duplication has played a central role in the genome evolution of many organisms, including the human genome. Most duplicated genes are eliminated, and factors that influence the retention of persisting duplicates remain poorly understood. We describe a systematic complex genetic interaction analysis with yeast paralogs derived from the whole-genome duplication event. Mapping of digenic interactions for a deletion mutant of each paralog, and of trigenic interactions for the double mutant, provides insight into their roles and a quantitative measure of their functional redundancy. Trigenic interaction analysis distinguishes two classes of paralogs: a more functionally divergent subset and another that retained more functional overlap. Gene feature analysis and modeling suggest that evolutionary trajectories of duplicated genes are dictated by combined functional and structural entanglement factors.
Identifiants
pubmed: 32586993
pii: 368/6498/eaaz5667
doi: 10.1126/science.aaz5667
pmc: PMC7539174
mid: NIHMS1632180
pii:
doi:
Substances chimiques
Membrane Proteins
0
PEX25 protein, S cerevisiae
0
Peroxins
0
Pex27 protein, S cerevisiae
0
Saccharomyces cerevisiae Proteins
0
Banques de données
Dryad
['10.5061/dryad.g79cnp5m9']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHGRI NIH HHS
ID : R01 HG005084
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG005853
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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