Determination of binding constants for strong complexation by affinity capillary electrophoresis: the example of complexes of ester betulin derivatives with (2-hydroxypropyl)-γ-cyclodextrin.
Betulin derivatives
Electromigration dispersion
Haarhoff-Van der Linde function
High-affinity interaction
Inclusion complexes
Stability constants
Journal
Analytical and bioanalytical chemistry
ISSN: 1618-2650
Titre abrégé: Anal Bioanal Chem
Pays: Germany
ID NLM: 101134327
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
18
05
2020
accepted:
17
06
2020
revised:
12
06
2020
pubmed:
4
7
2020
medline:
24
4
2021
entrez:
4
7
2020
Statut:
ppublish
Résumé
Complexation plays an important role in many biological phenomena, the analysis of different samples, optimization of separation processes, and increasing the pharmacological activity of drugs. This paper discusses the features of using mobility shift affinity capillary electrophoresis for studying strong complexation. Electrophoretic peaks for this case are often triangular. It was shown that the use of electrophoretic mobility obtained from the peak apex time to calculate binding constants leads to significant systematic and random errors, and the parameter a
Identifiants
pubmed: 32617760
doi: 10.1007/s00216-020-02777-4
pii: 10.1007/s00216-020-02777-4
doi:
Substances chimiques
Esters
0
Triterpenes
0
gamma-Cyclodextrins
0
betulin
6W70HN7X7O
(2-hydroxypropyl)-gamma-cyclodextrin
P6BYU725IU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5615-5625Subventions
Organisme : Russian Academy of Sciences
ID : АААА-А17-117021310221-7
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