Mechanistic characterization of UDP-glucuronic acid 4-epimerase.

Bacillus cereus / enzymology Bacterial Proteins / genetics Biocatalysis Carbohydrate Sequence Catalytic Domain Chromatography, High Pressure Liquid Escherichia coli / genetics Hydrogen-Ion Concentration Kinetics Magnetic Resonance Spectroscopy Molecular Sequence Data Mutant Proteins / metabolism Mutation Racemases and Epimerases / genetics Recombinant Proteins / genetics Uridine Diphosphate Sugars / chemistry
UDP-glucuronic acid decarboxylase epimerase kinetic isotope effect short-chain dehydrogenase/reductase

Journal

The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646

Informations de publication

Date de publication:
02 2021
Historique:
received: 06 03 2020
revised: 22 06 2020
accepted: 06 07 2020
pubmed: 10 7 2020
medline: 27 7 2021
entrez: 10 7 2020
Statut: ppublish

Résumé

UDP-glucuronic acid (UDP-GlcA) is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Despite the different reactions catalyzed, the enzymes are believed to share mechanistic analogy rooted in their joint membership to the short-chain dehydrogenase/reductase (SDR) protein superfamily: Oxidation at the substrate C4 by enzyme-bound NAD

Identifiants

DOI: 10.1111/febs.15478 PMID: 32645249 PMC: PMC7984243
pubmed: 32645249
doi: 10.1111/febs.15478
pmc: PMC7984243
doi:

Substances chimiques

Bacterial Proteins 0
Mutant Proteins 0
Recombinant Proteins 0
Uridine Diphosphate Sugars 0
UDP-galacturonic acid 50722-58-2
Racemases and Epimerases EC 5.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1163-1178

Informations de copyright

© 2020 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

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Auteurs

Annika J E Borg (AJE)

Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Austria.
ORCID: 0000-0003-1311-6910

Alexander Dennig (A)

Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Austria.
Austrian Centre of Industrial Biotechnology, Graz, Austria.

Hansjörg Weber (H)

Institute of Organic Chemistry, Graz University of Technology, NAWI Graz, Austria.

Bernd Nidetzky (B)

Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, NAWI Graz, Austria.
Austrian Centre of Industrial Biotechnology, Graz, Austria.
ORCID: 0000-0002-5030-2643

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Classifications MeSH

questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › Bacillaceae › Bacillus › Bacillus cereus › Mechanistic characterization of UDP-glucuronic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Mechanistic characterization of UDP-glucuronic...
questionsmedicales.fr › Métabolisme › Biocatalyse › Mechanistic characterization of UDP-glucuronic...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence glucidique › Mechanistic characterization of UDP-glucuronic...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › Mechanistic characterization of UDP-glucuronic...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Mechanistic characterization of UDP-glucuronic...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Mechanistic characterization of UDP-glucuronic...
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › Mechanistic characterization of UDP-glucuronic...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Mechanistic characterization of UDP-glucuronic...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Mechanistic characterization of UDP-glucuronic...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Mechanistic characterization of UDP-glucuronic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mutantes › Mechanistic characterization of UDP-glucuronic...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mechanistic characterization of UDP-glucuronic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › Racémases et épimérases › Mechanistic characterization of UDP-glucuronic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › Mechanistic characterization of UDP-glucuronic...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides uridyliques › Uridine diphosphate › Uridine diphosphate ose › Mechanistic characterization of UDP-glucuronic...