Deep Sequencing of Small RNAs from Neurosurgical Extracellular Vesicles Substantiates miR-486-3p as a Circulating Biomarker that Distinguishes Glioblastoma from Lower-Grade Astrocytoma Patients.

Astrocytoma / blood Biomarkers, Tumor / analysis Body Fluids / chemistry Brain Chemistry Brain Neoplasms / blood Cell-Derived Microparticles / chemistry Centrifugation, Density Gradient Diagnosis, Differential Glioblastoma / blood High-Throughput Nucleotide Sequencing Humans Liquid Biopsy MicroRNAs / analysis Neoplasm Grading Neurosurgical Procedures Organ Specificity RNA, Neoplasm / analysis RNA, Small Interfering / analysis RNA-Seq Tumor Microenvironment
extracellular vesicle glioblastoma glioma miRNA next generation sequencing piRNA small RNA

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
13 Jul 2020
Historique:
received: 29 05 2020
revised: 01 07 2020
accepted: 07 07 2020
entrez: 17 7 2020
pubmed: 17 7 2020
medline: 3 3 2021
Statut: epublish

Résumé

Extracellular vesicles (EVs) play key roles in glioblastoma (GBM; astrocytoma grade IV) biology and are novel sources of biomarkers. EVs released from GBM tumors can cross the blood-brain-barrier into the periphery carrying GBM molecules, including small non-coding RNA (sncRNA). Biomarkers cargoed in circulating EVs have shown great promise for assessing the molecular state of brain tumors in situ. Neurosurgical aspirate fluids captured during tumor resections are a rich source of GBM-EVs isolated directly from tumor microenvironments. Using density gradient ultracentrifugation, EVs were purified from cavitron ultrasonic surgical aspirate (CUSA) washings from GBM (

Identifiants

DOI: 10.3390/ijms21144954 PMID: 32668808 PMC: PMC7404297
pubmed: 32668808
pii: ijms21144954
doi: 10.3390/ijms21144954
pmc: PMC7404297
pii:
doi:

Substances chimiques

Biomarkers, Tumor 0
MIRN486 microRNA, human 0
MicroRNAs 0
RNA, Neoplasm 0
RNA, Small Interfering 0

Types de publication

Comparative Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Susannah Hallal (S)

Department of Neurosurgical Services, Chris O'Brien Lifehouse, Camperdown 2050, Australia.
Discipline of Pathology, School of Medical Sciences, The University of Sydney, Sydney 2006, Australia.
Brainstorm Brain Cancer Research, Brain and Mind Centre, The University of Sydney, Camperdown 2050, Australia.
Neuropathology Department, Royal Prince Alfred Hospital, Camperdown 2050, Australia.
ORCID: 0000-0002-9872-4917

Saeideh Ebrahim Khani (S)

Discipline of Pathology, School of Medical Sciences, The University of Sydney, Sydney 2006, Australia.

Heng Wei (H)

Brainstorm Brain Cancer Research, Brain and Mind Centre, The University of Sydney, Camperdown 2050, Australia.
Neuropathology Department, Royal Prince Alfred Hospital, Camperdown 2050, Australia.

Maggie Yuk Ting Lee (MYT)

Brainstorm Brain Cancer Research, Brain and Mind Centre, The University of Sydney, Camperdown 2050, Australia.
Neuropathology Department, Royal Prince Alfred Hospital, Camperdown 2050, Australia.

Hao-Wen Sim (HW)

Department of Medical Oncology and NHMRC Clinical Trials Centre, Chris O'Brien Lifehouse, Camperdown 2050, Australia.
Central Clinical School, The University of Sydney, Sydney 2006, Australia.
The Kinghorn Cancer Centre, St Vincent's Hospital, Darlinghurst 2010, Australia.

Joanne Sy (J)

Neuropathology Department, Royal Prince Alfred Hospital, Camperdown 2050, Australia.

Brindha Shivalingam (B)

Department of Neurosurgical Services, Chris O'Brien Lifehouse, Camperdown 2050, Australia.
Brainstorm Brain Cancer Research, Brain and Mind Centre, The University of Sydney, Camperdown 2050, Australia.

Michael E Buckland (ME)

Discipline of Pathology, School of Medical Sciences, The University of Sydney, Sydney 2006, Australia.
Brainstorm Brain Cancer Research, Brain and Mind Centre, The University of Sydney, Camperdown 2050, Australia.
Neuropathology Department, Royal Prince Alfred Hospital, Camperdown 2050, Australia.

Kimberley L Alexander-Kaufman (KL)

Department of Neurosurgical Services, Chris O'Brien Lifehouse, Camperdown 2050, Australia.
Discipline of Pathology, School of Medical Sciences, The University of Sydney, Sydney 2006, Australia.
Brainstorm Brain Cancer Research, Brain and Mind Centre, The University of Sydney, Camperdown 2050, Australia.
Neuropathology Department, Royal Prince Alfred Hospital, Camperdown 2050, Australia.
ORCID: 0000-0002-7239-039X

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Astrocytome › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Liquides et sécrétions biologiques › Liquides biologiques › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Métabolisme › Chimie du cerveau › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › Microparticules membranaires › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Ultracentrifugation › Centrifugation en gradient de densité › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Diagnostic › Diagnostic différentiel › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Astrocytome › Glioblastome › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Séquençage nucléotidique à haut débit › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytodiagnostic › Biopsie › Biopsie liquide › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Diagnostic › Pronostic › Grading des tumeurs › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de neurochirurgie › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Phénomènes physiologiques › Spécificité d'organe › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN tumoral › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ARN › RNA-Seq › Deep Sequencing of Small RNAs from...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Deep Sequencing of Small RNAs from...