Regulation of Ergosterol Biosynthesis in

DNA-Binding Proteins / genetics Drug Resistance, Fungal / genetics Ergosterol / biosynthesis Gene Expression Regulation, Fungal / genetics Promoter Regions, Genetic Repressor Proteins / genetics Saccharomyces cerevisiae / genetics Saccharomyces cerevisiae Proteins / genetics Sterols / metabolism Trans-Activators / genetics Transcription Factors / genetics
Saccharomyces cerevisiae ergosterol iron oxygen sterol biosynthesis sterol regulation yeast

Journal

Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097

Informations de publication

Date de publication:
15 07 2020
Historique:
received: 26 06 2020
revised: 06 07 2020
accepted: 13 07 2020
entrez: 19 7 2020
pubmed: 19 7 2020
medline: 16 3 2021
Statut: epublish

Résumé

Ergosterol is an essential component of fungal cell membranes that determines the fluidity, permeability and activity of membrane-associated proteins. Ergosterol biosynthesis is a complex and highly energy-consuming pathway that involves the participation of many enzymes. Deficiencies in sterol biosynthesis cause pleiotropic defects that limit cellular proliferation and adaptation to stress. Thereby, fungal ergosterol levels are tightly controlled by the bioavailability of particular metabolites (e.g., sterols, oxygen and iron) and environmental conditions. The regulation of ergosterol synthesis is achieved by overlapping mechanisms that include transcriptional expression, feedback inhibition of enzymes and changes in their subcellular localization. In the budding yeast

Identifiants

DOI: 10.3390/genes11070795 PMID: 32679672 PMC: PMC7397035
pubmed: 32679672
pii: genes11070795
doi: 10.3390/genes11070795
pmc: PMC7397035
pii:
doi:

Substances chimiques

DNA-Binding Proteins 0
ECM22 protein, S cerevisiae 0
HAP1 protein, S cerevisiae 0
MOT3 protein, S cerevisiae 0
ROX1 protein, S cerevisiae 0
Repressor Proteins 0
Saccharomyces cerevisiae Proteins 0
Sterols 0
Trans-Activators 0
Transcription Factors 0
UPC2 protein, S cerevisiae 0
Ergosterol Z30RAY509F

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Tania Jordá (T)

Departamento de Biotecnología, Instituto de Agroquímica y Tecnología de Alimentos (IATA), Consejo Superior de Investigaciones Científicas (CSIC), Agustín Escardino 7, E-46980 Paterna, Valencia, Spain.

Sergi Puig (S)

Departamento de Biotecnología, Instituto de Agroquímica y Tecnología de Alimentos (IATA), Consejo Superior de Investigaciones Científicas (CSIC), Agustín Escardino 7, E-46980 Paterna, Valencia, Spain.
ORCID: 0000-0002-1856-490X

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Regulation of Ergosterol Biosynthesis in
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance des champignons aux médicaments › Regulation of Ergosterol Biosynthesis in
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Cholestanes › Cholestènes › Ergostérol › Regulation of Ergosterol Biosynthesis in
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes fongiques › Regulation of Ergosterol Biosynthesis in
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Regulation of Ergosterol Biosynthesis in
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Regulation of Ergosterol Biosynthesis in
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Regulation of Ergosterol Biosynthesis in
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › Regulation of Ergosterol Biosynthesis in
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Regulation of Ergosterol Biosynthesis in
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales régulatrices ou accessoires › Transactivateurs › Regulation of Ergosterol Biosynthesis in
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Regulation of Ergosterol Biosynthesis in