Developmental function and state transitions of a gene expression oscillator in Caenorhabditis elegans.
Animals
Biological Clocks
/ genetics
Caenorhabditis elegans
/ embryology
Caenorhabditis elegans Proteins
/ genetics
Gastrulation
/ genetics
Gene Expression Profiling
Gene Expression Regulation, Developmental
/ genetics
Gene Ontology
Genes, Reporter
Humans
Larva
/ genetics
Models, Theoretical
Molting
/ genetics
Organ Specificity
RNA-Seq
Spatio-Temporal Analysis
Time Factors
SNIC
bifurcation
checkpoint
development
oscillator
Journal
Molecular systems biology
ISSN: 1744-4292
Titre abrégé: Mol Syst Biol
Pays: England
ID NLM: 101235389
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
04
02
2020
revised:
15
06
2020
accepted:
22
06
2020
entrez:
21
7
2020
pubmed:
21
7
2020
medline:
15
7
2021
Statut:
ppublish
Résumé
Gene expression oscillators can structure biological events temporally and spatially. Different biological functions benefit from distinct oscillator properties. Thus, finite developmental processes rely on oscillators that start and stop at specific times, a poorly understood behavior. Here, we have characterized a massive gene expression oscillator comprising > 3,700 genes in Caenorhabditis elegans larvae. We report that oscillations initiate in embryos, arrest transiently after hatching and in response to perturbation, and cease in adults. Experimental observation of the transitions between oscillatory and non-oscillatory states at high temporal resolution reveals an oscillator operating near a Saddle Node on Invariant Cycle (SNIC) bifurcation. These findings constrain the architecture and mathematical models that can represent this oscillator. They also reveal that oscillator arrests occur reproducibly in a specific phase. Since we find oscillations to be coupled to developmental processes, including molting, this characteristic of SNIC bifurcations endows the oscillator with the potential to halt larval development at defined intervals, and thereby execute a developmental checkpoint function.
Identifiants
pubmed: 32687264
doi: 10.15252/msb.20209498
pmc: PMC7370751
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Banques de données
GEO
['GSE133576']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e9498Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2020 The Authors. Published under the terms of the CC BY 4.0 license.
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