3D Printing of Microgel-Loaded Modular Microcages as Instructive Scaffolds for Tissue Engineering.
cell migration
growth factor delivery
instructive scaffolds
microgels
vascularization
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
11
03
2020
revised:
19
05
2020
pubmed:
24
7
2020
medline:
21
8
2021
entrez:
24
7
2020
Statut:
ppublish
Résumé
Biomaterial scaffolds have served as the foundation of tissue engineering and regenerative medicine. However, scaffold systems are often difficult to scale in size or shape in order to fit defect-specific dimensions, and thus provide only limited spatiotemporal control of therapeutic delivery and host tissue responses. Here, a lithography-based 3D printing strategy is used to fabricate a novel miniaturized modular microcage scaffold system, which can be assembled and scaled manually with ease. Scalability is based on an intuitive concept of stacking modules, like conventional toy interlocking plastic blocks, allowing for literally thousands of potential geometric configurations, and without the need for specialized equipment. Moreover, the modular hollow-microcage design allows each unit to be loaded with biologic cargo of different compositions, thus enabling controllable and easy patterning of therapeutics within the material in 3D. In summary, the concept of miniaturized microcage designs with such straight-forward assembly and scalability, as well as controllable loading properties, is a flexible platform that can be extended to a wide range of materials for improved biological performance.
Identifiants
pubmed: 32700332
doi: 10.1002/adma.202001736
doi:
Substances chimiques
Microgels
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2001736Subventions
Organisme : Michigan-Pittsburgh-Wyss Resource Center-Regenerative Medicine Resource Center
Organisme : NIDCR NIH HHS
ID : R01 DE026170
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01DE026170
Pays : United States
Organisme : Biomedical Innovation Program
Organisme : NIDCR NIH HHS
ID : 3R01DE026170-03S1
Pays : United States
Organisme : Oregon Clinical and Translational Research Institute
Informations de copyright
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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