Mechanisms of stretch-mediated skin expansion at single-cell resolution.

Adaptor Proteins, Signal Transducing / metabolism Adherens Junctions / metabolism Animals Base Sequence Cell Cycle Proteins / metabolism Cell Differentiation / drug effects Cell Self Renewal / drug effects Chromatin / drug effects Chromatin Assembly and Disassembly / drug effects Clone Cells / cytology Disease Models, Animal Extracellular Signal-Regulated MAP Kinases / metabolism Gene Regulatory Networks / drug effects Hydrogels / administration & dosage Mechanotransduction, Cellular / drug effects Mice Mice, Transgenic Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors Mutation RNA, Messenger / genetics RNA-Seq Single-Cell Analysis Skin / cytology Stem Cells / cytology Trans-Activators / antagonists & inhibitors Transcription Factor AP-1 / metabolism Transcription, Genetic / drug effects YAP-Signaling Proteins

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
08 2020
Historique:
received: 19 02 2019
accepted: 19 06 2020
pubmed: 31 7 2020
medline: 15 9 2020
entrez: 31 7 2020
Statut: ppublish

Résumé

The ability of the skin to grow in response to stretching has been exploited in reconstructive surgery

Identifiants

DOI: 10.1038/s41586-020-2555-7 PMID: 32728211 PMC: PMC7116042
pubmed: 32728211
doi: 10.1038/s41586-020-2555-7
pii: 10.1038/s41586-020-2555-7
pmc: PMC7116042
mid: EMS94010
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
Cell Cycle Proteins 0
Chromatin 0
Hydrogels 0
Mrtfa protein, mouse 0
RNA, Messenger 0
Trans-Activators 0
Transcription Factor AP-1 0
YAP-Signaling Proteins 0
Yap1 protein, mouse 0
Extracellular Signal-Regulated MAP Kinases EC 2.7.11.24
Mitogen-Activated Protein Kinase Kinases EC 2.7.12.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

268-273

Subventions

Organisme : Medical Research Council
ID : MC_PC_12009
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 092096
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 098357/Z/12/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17230
Pays : United Kingdom
Organisme : European Research Council
ID : 616333
Pays : International

Commentaires et corrections

Type : CommentIn

Références

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Auteurs

Mariaceleste Aragona (M)

Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles, Brussels, Belgium.

Alejandro Sifrim (A)

Department of Human Genetics, University of Leuven, KU Leuven, Leuven, Belgium.
Sanger Institute-EBI Single-Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, UK.

Milan Malfait (M)

Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles, Brussels, Belgium.
ORCID: 0000-0001-9144-3701

Yura Song (Y)

Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles, Brussels, Belgium.
ORCID: 0000-0002-1173-9172

Jens Van Herck (J)

Department of Human Genetics, University of Leuven, KU Leuven, Leuven, Belgium.
Sanger Institute-EBI Single-Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, UK.
ORCID: 0000-0002-1291-4462

Sophie Dekoninck (S)

Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles, Brussels, Belgium.

Souhir Gargouri (S)

Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles, Brussels, Belgium.

Gaëlle Lapouge (G)

Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles, Brussels, Belgium.

Benjamin Swedlund (B)

Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles, Brussels, Belgium.
ORCID: 0000-0002-8264-9342

Christine Dubois (C)

Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles, Brussels, Belgium.

Pieter Baatsen (P)

Electron Microscopy Platform of VIB Bio Imaging Core, Leuven, Belgium.

Katlijn Vints (K)

Electron Microscopy Platform of VIB Bio Imaging Core, Leuven, Belgium.

Seungmin Han (S)

The Wellcome Trust-Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.
Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.

Fadel Tissir (F)

Université Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology, Brussels, Belgium.
ORCID: 0000-0002-9292-6622

Thierry Voet (T)

Department of Human Genetics, University of Leuven, KU Leuven, Leuven, Belgium.
Sanger Institute-EBI Single-Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, UK.

Benjamin D Simons (BD)

The Wellcome Trust-Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK. bds10@cam.ac.uk.
Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK. bds10@cam.ac.uk.
Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, UK. bds10@cam.ac.uk.
ORCID: 0000-0002-3875-7071

Cédric Blanpain (C)

Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles, Brussels, Belgium. cedric.blanpain@ulb.ac.be.
WELBIO, Université Libre de Bruxelles, Brussels, Belgium. cedric.blanpain@ulb.ac.be.
ORCID: 0000-0002-4028-4322

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Jonctions adhérentes › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Eucaryotes › Animaux › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence nucléotidique › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Division cellulaire › Auto-renouvellement cellulaire › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Assemblage et désassemblage de la chromatine › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Cellules › Cellules cultivées › Clones cellulaires › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › Extracellular Signal-Regulated MAP Kinases › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Réseaux de régulation génique › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Mécanotransduction cellulaire › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Mitogen-Activated Protein Kinase Kinases › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ARN › RNA-Seq › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Système tégumentaire › Peau › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Cellules › Cellules souches › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales régulatrices ou accessoires › Transactivateurs › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteur de transcription AP-1 › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Mechanisms of stretch-mediated skin expansion...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Protéines de signalisation YAP › Mechanisms of stretch-mediated skin expansion...