The Biosynthetic Gene Cluster for Sestermobaraenes-Discovery of a Geranylfarnesyl Diphosphate Synthase and a Multiproduct Sesterterpene Synthase from Streptomyces mobaraensis.
Streptomyces mobaraensis
biosynthetic gene cluster
configuration determination
enzyme catalysis
terpenes
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
02 11 2020
02 11 2020
Historique:
received:
22
07
2020
pubmed:
5
8
2020
medline:
30
3
2021
entrez:
5
8
2020
Statut:
ppublish
Résumé
A biosynthetic gene cluster from Streptomyces mobaraensis encoding the first cases of a bacterial geranylfarnesyl diphosphate synthase and a type I sesterterpene synthase was identified. The structures of seven sesterterpenes produced by these enzymes were elucidated, including their absolute configurations. The enzyme mechanism of the sesterterpene synthase was investigated by extensive isotope labeling experiments.
Identifiants
pubmed: 32749032
doi: 10.1002/anie.202010084
pmc: PMC7693059
doi:
Substances chimiques
Sesterterpenes
0
Gefarnate
1ISE2Y6ULA
geranylfarnesol
79577-58-5
Ligases
EC 6.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19961-19965Informations de copyright
© 2020 The Authors. Published by Wiley-VCH GmbH.
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