Temporal lobe regions essential for preserved picture naming after left temporal epilepsy surgery.
Adult
Anomia
/ etiology
Anterior Temporal Lobectomy
/ adverse effects
Brain Mapping
Drug Resistant Epilepsy
/ surgery
Epilepsy, Temporal Lobe
/ surgery
Female
Functional Neuroimaging
Hippocampus
/ diagnostic imaging
Humans
Language Tests
Magnetic Resonance Imaging
Male
Middle Aged
Postoperative Complications
/ etiology
Temporal Lobe
/ diagnostic imaging
Young Adult
anomia
epilepsy
fusiform gyrus
lesion localization
temporal lobe
Journal
Epilepsia
ISSN: 1528-1167
Titre abrégé: Epilepsia
Pays: United States
ID NLM: 2983306R
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
18
05
2020
revised:
10
07
2020
accepted:
20
07
2020
pubmed:
12
8
2020
medline:
26
1
2021
entrez:
12
8
2020
Statut:
ppublish
Résumé
To define left temporal lobe regions where surgical resection produces a persistent postoperative decline in naming visual objects. Pre- and postoperative brain magnetic resonance imaging data and picture naming (Boston Naming Test) scores were obtained prospectively from 59 people with drug-resistant left temporal lobe epilepsy. All patients had left hemisphere language dominance at baseline and underwent surgical resection or ablation in the left temporal lobe. Postoperative naming assessment occurred approximately 7 months after surgery. Surgical lesions were mapped to a standard template, and the relationship between presence or absence of a lesion and the degree of naming decline was tested at each template voxel while controlling for effects of overall lesion size. Patients declined by an average of 15% in their naming score, with wide variation across individuals. Decline was significantly related to damage in a cluster of voxels in the ventral temporal lobe, located mainly in the fusiform gyrus approximately 4-6 cm posterior to the temporal tip. Extent of damage to this region explained roughly 50% of the variance in outcome. Picture naming decline was not related to hippocampal or temporal pole damage. The results provide the first statistical map relating lesion location in left temporal lobe epilepsy surgery to picture naming decline, and they support previous observations of transient naming deficits from electrical stimulation in the basal temporal cortex. The critical lesion is relatively posterior and could be avoided in many patients undergoing left temporal lobe surgery for intractable epilepsy.
Identifiants
pubmed: 32780878
doi: 10.1111/epi.16643
pmc: PMC7722029
mid: NIHMS1637771
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1939-1948Subventions
Organisme : NINDS NIH HHS
ID : K02 NS070960
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103537
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS035929
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS088748
Pays : United States
Informations de copyright
© 2020 International League Against Epilepsy.
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