Strain-Level Metagenomic Data Analysis of Enriched In Vitro and In Silico Spiked Food Samples: Paving the Way towards a Culture-Free Foodborne Outbreak Investigation Using STEC as a Case Study.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
08 Aug 2020
Historique:
received: 13 07 2020
revised: 04 08 2020
accepted: 06 08 2020
entrez: 14 8 2020
pubmed: 14 8 2020
medline: 20 2 2021
Statut: epublish

Résumé

Culture-independent diagnostics, such as metagenomic shotgun sequencing of food samples, could not only reduce the turnaround time of samples in an outbreak investigation, but also allow the detection of multi-species and multi-strain outbreaks. For successful foodborne outbreak investigation using a metagenomic approach, it is, however, necessary to bioinformatically separate the genomes of individual strains, including strains belonging to the same species, present in a microbial community, which has up until now not been demonstrated for this application. The current work shows the feasibility of strain-level metagenomics of enriched food matrix samples making use of data analysis tools that classify reads against a sequence database. It includes a brief comparison of two database-based read classification tools, Sigma and Sparse, using a mock community obtained by in vitro spiking minced meat with a Shiga toxin-producing

Identifiants

pubmed: 32784459
pii: ijms21165688
doi: 10.3390/ijms21165688
pmc: PMC7460976
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Belgian Federal Public Service of Health, Food Chain Safety and Environment
ID : RF 17/6316 StEQIDEMIC.be
Organisme : Sciensano
ID : contract RP NeXSplorer.iph and .Be READY

Références

Arch Public Health. 2014 Dec 15;72(1):44
pubmed: 25810911
Infect Genet Evol. 2016 Jun;40:389-397
pubmed: 26391184
BMC Microbiol. 2016 Nov 16;16(1):275
pubmed: 27852235
Genetics. 2014 Jul;197(3):925-37
pubmed: 24793089
Appl Microbiol Biotechnol. 2018 Apr;102(7):3267-3285
pubmed: 29460001
PLoS One. 2016 Dec 8;11(12):e0167870
pubmed: 27930729
Implement Sci. 2019 Aug 13;14(1):79
pubmed: 31409417
Nat Commun. 2017 Dec 22;8(1):2260
pubmed: 29273717
N Engl J Med. 2011 Aug 25;365(8):709-17
pubmed: 21793740
J Appl Microbiol. 2008 Nov;105(5):1259-65
pubmed: 18713293
Bioinformatics. 2017 Jul 15;33(14):i124-i132
pubmed: 28881972
Front Microbiol. 2017 May 01;8:777
pubmed: 28507541
Euro Surveill. 2011 Jun 16;16(24):
pubmed: 21699770
EFSA J. 2019 Dec 03;17(12):e05898
pubmed: 32626197
Genome Med. 2014 Nov 20;6(11):90
pubmed: 25422674
BMC Microbiol. 2015 Aug 12;15:160
pubmed: 26264042
Genome Announc. 2018 Jan 11;6(2):
pubmed: 29326203
Genome Biol. 2017 Sep 21;18(1):181
pubmed: 28934976
PLoS One. 2013 Sep 09;8(9):e73079
pubmed: 24039862
Microbiome. 2014 Sep 05;2:33
pubmed: 25225611
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Clin Microbiol Rev. 2013 Oct;26(4):822-80
pubmed: 24092857
Bioinformatics. 2016 Jan 15;32(2):292-4
pubmed: 26428292
BMC Bioinformatics. 2011 Apr 26;12:119
pubmed: 21521499
Bioinformatics. 2014 May 1;30(9):1312-3
pubmed: 24451623
BMC Bioinformatics. 2012 Aug 21;13:209
pubmed: 22909249
Microb Genom. 2016 Apr 29;2(4):e000056
pubmed: 28348851
Front Microbiol. 2019 Aug 06;10:1805
pubmed: 31447815
Microbiome. 2018 Mar 20;6(1):50
pubmed: 29554948
Appl Environ Microbiol. 2017 Aug 1;83(16):
pubmed: 28625983
Nat Biotechnol. 2015 Oct;33(10):1045-52
pubmed: 26344404
Int J Food Microbiol. 2018 Dec 20;287:3-9
pubmed: 29246458
BMC Genomics. 2017 May 8;18(1):359
pubmed: 28482799
Food Microbiol. 2019 Jun;79:96-115
pubmed: 30621881
Nat Methods. 2016 May;13(5):435-8
pubmed: 26999001
Nucleic Acids Res. 2015 Sep 18;43(16):e105
pubmed: 25990729
BMC Genomics. 2018 Dec 27;19(1):968
pubmed: 30587114
J Clin Microbiol. 2015 Aug;53(8):2410-26
pubmed: 25972421
Genome Announc. 2015 Mar 26;3(2):
pubmed: 25814601
Nucleic Acids Res. 2017 Jan 25;45(2):e7
pubmed: 27651451
Microbiol Spectr. 2014 Dec;2(6):
pubmed: 26104460
J Clin Microbiol. 2014 Jul;52(7):2365-70
pubmed: 24759713
Bioinformatics. 2011 Nov 1;27(21):2987-93
pubmed: 21903627
Genome Res. 2017 Apr;27(4):626-638
pubmed: 28167665
Bioinformatics. 2015 Jan 15;31(2):170-7
pubmed: 25266224
Front Microbiol. 2017 Oct 20;8:2029
pubmed: 29104564
Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19126-31
pubmed: 19855009
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Appl Environ Microbiol. 2015 Dec;81(23):8183-91
pubmed: 26386062
Cell Host Microbe. 2018 Feb 14;23(2):229-240.e5
pubmed: 29447696
Front Microbiol. 2017 Jul 04;8:1069
pubmed: 28725217
J Clin Microbiol. 2014 May;52(5):1501-10
pubmed: 24574290
BMC Genomics. 2018 Aug 31;19(1):647
pubmed: 30170539
PLoS One. 2014 May 20;9(5):e98103
pubmed: 24844597
Genome Biol. 2019 Nov 28;20(1):257
pubmed: 31779668
Genome Biol. 2016 Jun 20;17(1):132
pubmed: 27323842

Auteurs

Assia Saltykova (A)

Transversal Activities in Applied Genomics (TAG), Sciensano, 1050 Brussels, Belgium.
IDLab, Department of Information Technology, Ghent University, IMEC, 9052 Ghent, Belgium.

Florence E Buytaers (FE)

Transversal Activities in Applied Genomics (TAG), Sciensano, 1050 Brussels, Belgium.
IDLab, Department of Information Technology, Ghent University, IMEC, 9052 Ghent, Belgium.

Sarah Denayer (S)

National Reference Laboratory for Shiga Toxin-Producing Escherichia coli (NRL STEC), Foodborne Pathogens, Sciensano, 1050 Brussels, Belgium.

Bavo Verhaegen (B)

National Reference Laboratory for Shiga Toxin-Producing Escherichia coli (NRL STEC), Foodborne Pathogens, Sciensano, 1050 Brussels, Belgium.

Denis Piérard (D)

National Reference Center for Shiga Toxin-Producing Escherichia coli (NRC STEC), Department of Microbiology and Infection Control, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium.

Nancy H C Roosens (NHC)

Transversal Activities in Applied Genomics (TAG), Sciensano, 1050 Brussels, Belgium.

Kathleen Marchal (K)

IDLab, Department of Information Technology, Ghent University, IMEC, 9052 Ghent, Belgium.
Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.
Department of Genetics, University of Pretoria, Pretoria 0083, South Africa.

Sigrid C J De Keersmaecker (SCJ)

Transversal Activities in Applied Genomics (TAG), Sciensano, 1050 Brussels, Belgium.

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Classifications MeSH