DNA-Compatible Copper-Catalyzed Oxidative Amidation of Aldehydes with Non-Nucleophilic Arylamines.
Journal
Bioconjugate chemistry
ISSN: 1520-4812
Titre abrégé: Bioconjug Chem
Pays: United States
ID NLM: 9010319
Informations de publication
Date de publication:
16 09 2020
16 09 2020
Historique:
pubmed:
18
8
2020
medline:
22
6
2021
entrez:
18
8
2020
Statut:
ppublish
Résumé
We report a DNA-compatible protocol for synthesizing amides from DNA-bound aldehydes and non-nucleophilic arylamines including aza-substituted anilines, 2-aminobenzimidazoles, and 3-aminopyrazoles. The reactions were carried out at room temperature and provided reasonable conversions and wide functional group compatibility. The reactions were also successful when employing aryl and aliphatic aldehydes. In addition, qPCR and NGS data suggested no negative impact on DNA integrity after the copper-mediated oxidative amidation reaction.
Identifiants
pubmed: 32804494
doi: 10.1021/acs.bioconjchem.0c00392
doi:
Substances chimiques
Aldehydes
0
Amides
0
Amines
0
Aniline Compounds
0
Copper
789U1901C5
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM