Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage.
Animals
Antibodies, Monoclonal
/ therapeutic use
Antigens, Neoplasm
/ immunology
Antineoplastic Agents, Alkylating
/ therapeutic use
Bacteriophages
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Cross Reactions
Cyclophosphamide
/ therapeutic use
Enterococcus hirae
/ virology
Epitopes
/ immunology
Feces
/ virology
Gastrointestinal Microbiome
/ immunology
H-2 Antigens
/ immunology
Histocompatibility Antigens Class I
/ immunology
Humans
Immunotherapy
/ methods
Mice
Neoplasms
/ diet therapy
Programmed Cell Death 1 Receptor
/ antagonists & inhibitors
Viral Tail Proteins
/ immunology
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
21 08 2020
21 08 2020
Historique:
received:
19
03
2019
revised:
28
02
2020
accepted:
23
06
2020
entrez:
22
8
2020
pubmed:
21
8
2020
medline:
22
9
2020
Statut:
ppublish
Résumé
Intestinal microbiota have been proposed to induce commensal-specific memory T cells that cross-react with tumor-associated antigens. We identified major histocompatibility complex (MHC) class I-binding epitopes in the tail length tape measure protein (TMP) of a prophage found in the genome of the bacteriophage
Identifiants
pubmed: 32820119
pii: 369/6506/936
doi: 10.1126/science.aax0701
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antigens, Neoplasm
0
Antineoplastic Agents, Alkylating
0
Epitopes
0
H-2 Antigens
0
H-2Kb protein, mouse
0
Histocompatibility Antigens Class I
0
Programmed Cell Death 1 Receptor
0
Viral Tail Proteins
0
Cyclophosphamide
8N3DW7272P
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
936-942Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.