Failure of tofacitinib to achieve an objective response in a
Aged
Cell Transformation, Neoplastic
/ genetics
DEAD-box RNA Helicases
/ genetics
Drug Resistance, Neoplasm
/ genetics
Female
Humans
Janus Kinase 1
/ genetics
Janus Kinase 3
/ genetics
Piperidines
/ therapeutic use
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/ drug therapy
Pyrimidines
/ therapeutic use
Transcription Factors
/ genetics
Exome Sequencing
T-cell acute lymphoblastic leukemias
hematological neoplasm
leukemia
Journal
Cold Spring Harbor molecular case studies
ISSN: 2373-2873
Titre abrégé: Cold Spring Harb Mol Case Stud
Pays: United States
ID NLM: 101660017
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
19
11
2019
accepted:
05
06
2020
entrez:
27
8
2020
pubmed:
28
8
2020
medline:
7
7
2021
Statut:
epublish
Résumé
T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia (T-LBL/T ALL) is an aggressive hematological malignancy arising from malignant transformation of T-cell progenitors with poor prognosis in adult patients. Outcomes are particularly dismal in the relapsed/refractory setting, and therapeutic options are limited in this context. Genomic profiling has shown frequent aberrations in the JAK-STAT pathway, including recurrent mutations in
Identifiants
pubmed: 32843425
pii: mcs.a004994
doi: 10.1101/mcs.a004994
pmc: PMC7476415
pii:
doi:
Substances chimiques
MLLT10 protein, human
0
Piperidines
0
Pyrimidines
0
Transcription Factors
0
tofacitinib
87LA6FU830
JAK1 protein, human
EC 2.7.10.2
JAK3 protein, human
EC 2.7.10.2
Janus Kinase 1
EC 2.7.10.2
Janus Kinase 3
EC 2.7.10.2
DDX3X protein, human
EC 3.6.1.-
DEAD-box RNA Helicases
EC 3.6.4.13
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2020 Wong et al.; Published by Cold Spring Harbor Laboratory Press.
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