Retinoic acid promotes metabolic maturation of human Embryonic Stem Cell-derived Cardiomyocytes.
Animals
Cell Differentiation
/ drug effects
Cell Line
Fatty Acids
/ metabolism
Human Embryonic Stem Cells
/ drug effects
Humans
Mice
Mice, Inbred ICR
Myocytes, Cardiac
/ drug effects
Oxidative Phosphorylation
/ drug effects
Pyruvic Acid
/ metabolism
Sequence Analysis, RNA
/ methods
Signal Transduction
/ drug effects
Tretinoin
/ pharmacology
Up-Regulation
/ drug effects
Cardiomyocyte differentiation
Cardiomyocyte maturation
Embryonic stem cells
Oxidative phosphorylation
Retinoic acid
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
01
2020
accepted:
20
07
2020
entrez:
1
9
2020
pubmed:
31
8
2020
medline:
26
5
2021
Statut:
epublish
Résumé
Cardiomyocytes differentiated from human embryonic stem cells (hESCs) represent a promising cell source for heart repair, disease modeling and drug testing. However, improving the differentiation efficiency and maturation of hESC-derived cardiomyocytes (hESC-CMs) is still a major concern. Retinoic acid (RA) signaling plays multiple roles in heart development. However, the effects of RA on cardiomyocyte differentiation efficiency and maturation are still unknown.
Identifiants
pubmed: 32863954
doi: 10.7150/thno.44146
pii: thnov10p9686
pmc: PMC7449904
doi:
Substances chimiques
Fatty Acids
0
Tretinoin
5688UTC01R
Pyruvic Acid
8558G7RUTR
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9686-9701Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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