Molecular Genetic Analysis of α-Thalassemia in Hamadan Province, West Iran.
Adult
Alleles
Biomarkers
Case-Control Studies
Erythrocyte Indices
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Geography, Medical
Humans
Iran
/ epidemiology
Male
Mutation
Population Surveillance
Sequence Analysis, DNA
Young Adult
alpha-Globins
/ genetics
alpha-Thalassemia
/ diagnosis
West Iran
gene
mutation
α-Thalassemia (α-thal)
Journal
Hemoglobin
ISSN: 1532-432X
Titre abrégé: Hemoglobin
Pays: England
ID NLM: 7705865
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
pubmed:
8
9
2020
medline:
13
7
2021
entrez:
7
9
2020
Statut:
ppublish
Résumé
Identifying couples who are carriers of thalassemia-causing mutations, followed by prenatal diagnosis (PND), is undoubtedly an effective way to prevent the birth of children with the disease. Our aim in this study was to report for the first time the spectrum of α-globin gene mutations in the population living in Hamadan Province, West Iran. Multiplex gap-polymerase chain reaction (gap-PCR), amplification refractory mutation system (ARMS)-PCR, and direct DNA sequencing of
Identifiants
pubmed: 32893703
doi: 10.1080/03630269.2020.1800487
doi:
Substances chimiques
Biomarkers
0
alpha-Globins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM