Elucidating aromatic acid tolerance at low pH in
Acids
/ metabolism
Adaptation, Physiological
/ genetics
Amino Acids, Aromatic
/ metabolism
Coumaric Acids
/ metabolism
Directed Molecular Evolution
Drug Tolerance
/ genetics
Membrane Transport Proteins
/ genetics
Saccharomyces cerevisiae
/ metabolism
Saccharomyces cerevisiae Proteins
/ genetics
Trans-Activators
/ genetics
Transcription Factors
/ metabolism
Whole Genome Sequencing
/ methods
adaptive laboratory evolution
aromatic acid
tolerance
transporter
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
10 11 2020
10 11 2020
Historique:
pubmed:
28
10
2020
medline:
8
1
2021
entrez:
27
10
2020
Statut:
ppublish
Résumé
Toxicity from the external presence or internal production of compounds can reduce the growth and viability of microbial cell factories and compromise productivity. Aromatic compounds are generally toxic for microorganisms, which makes their production in microbial hosts challenging. Here we use adaptive laboratory evolution to generate
Identifiants
pubmed: 33106428
pii: 2013044117
doi: 10.1073/pnas.2013044117
pmc: PMC7668050
doi:
Substances chimiques
Acids
0
Amino Acids, Aromatic
0
Aro80 protein, S cerevisiae
0
Coumaric Acids
0
ESBP6 protein, S cerevisiae
0
Membrane Transport Proteins
0
Saccharomyces cerevisiae Proteins
0
Trans-Activators
0
Transcription Factors
0
ferulic acid
AVM951ZWST
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
27954-27961Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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