Selective Stimulation of Duplicated Atlantic Salmon MHC Pathway Genes by Interferon-Gamma.
Animals
Cell Line
Evolution, Molecular
Fish Proteins
/ genetics
Gene Duplication
Gene Expression Regulation
Head Kidney
/ pathology
Histocompatibility Antigens Class I
/ genetics
Interferon Regulatory Factor-1
/ genetics
Interferon-gamma
/ metabolism
Intracellular Signaling Peptides and Proteins
/ genetics
Major Histocompatibility Complex
/ genetics
Nuclear Proteins
/ genetics
Phylogeny
Promoter Regions, Genetic
/ genetics
Salmo salar
/ genetics
Trans-Activators
/ genetics
Zebrafish
/ genetics
Atlantic salmon
MHC pathways
antigen presentation
homeologs
interferon gamma
teleost
whole genome duplications
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
11
06
2020
accepted:
25
08
2020
entrez:
30
10
2020
pubmed:
31
10
2020
medline:
1
6
2021
Statut:
epublish
Résumé
Induction of cellular immune responses rely on Major histocompatibility complex (MHC) molecules presenting pathogenic peptides to T cells. Peptide processing, transport, loading and editing is a constitutive process in most cell types, but is accelerated upon infection. Recently, an unexpected complexity in the number of functional genes involved in MHC class I peptide cleavage, peptide transport, peptide loading and editing was found in teleosts, originating from the second and third whole genome duplication events. Salmonids have expanded upon this with functional duplicates also from a fourth unique salmonid whole genome duplication. However, little is known about how individual gene duplicates respond in the context of stimulation. Here we set out to investigate how interferon gamma (IFNg) regulates the transcription of immune genes in Atlantic salmon with particular focus on gene duplicates and MHC pathways. We identified a range of response patterns in Atlantic salmon gene duplicates, with upregulation of all duplicates for some genes, like interferon regulatory factor 1 (IRF1) and interferon induced protein 44-like (IFI44.L), but only induction of one or a few duplicates of other genes, such as TAPBP and ERAP2. A master regulator turned out to be the IRF1 and not the enhanceosome as seen in mammals. If IRF1 also collaborates with CIITA and possibly NLRC5 in regulating IFNg induction of MHCI and MHCII expression in Atlantic salmon, as in zebrafish, remains to be established. Altogether, our results show the importance of deciphering between gene duplicates, as they often respond very differently to stimulation and may have different biological functions.
Identifiants
pubmed: 33123146
doi: 10.3389/fimmu.2020.571650
pmc: PMC7573153
doi:
Substances chimiques
Fish Proteins
0
Histocompatibility Antigens Class I
0
Interferon Regulatory Factor-1
0
Intracellular Signaling Peptides and Proteins
0
MHC class II transactivator protein
0
Nuclear Proteins
0
Trans-Activators
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
571650Informations de copyright
Copyright © 2020 Grimholt, Fosse and Sundaram.
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