Efficient detection of copy-number variations using exome data: Batch- and sex-based analyses.


Journal

Human mutation
ISSN: 1098-1004
Titre abrégé: Hum Mutat
Pays: United States
ID NLM: 9215429

Informations de publication

Date de publication:
01 2021
Historique:
received: 20 06 2020
revised: 29 09 2020
accepted: 15 10 2020
pubmed: 2 11 2020
medline: 1 4 2022
entrez: 1 11 2020
Statut: ppublish

Résumé

Many algorithms to detect copy number variations (CNVs) using exome sequencing (ES) data have been reported and evaluated on their sensitivity and specificity, reproducibility, and precision. However, operational optimization of such algorithms for a better performance has not been fully addressed. ES of 1199 samples including 763 patients with different disease profiles was performed. ES data were analyzed to detect CNVs by both the eXome Hidden Markov Model (XHMM) and modified Nord's method. To efficiently detect rare CNVs, we aimed to decrease sequencing biases by analyzing, at the same time, the data of all unrelated samples sequenced in the same flow cell as a batch, and to eliminate sex effects of X-linked CNVs by analyzing female and male sequences separately. We also applied several filtering steps for more efficient CNV selection. The average number of CNVs detected in one sample was <5. This optimization together with targeted CNV analysis by Nord's method identified pathogenic/likely pathogenic CNVs in 34 patients (4.5%, 34/763). In particular, among 142 patients with epilepsy, the current protocol detected clinically relevant CNVs in 19 (13.4%) patients, whereas the previous protocol identified them in only 14 (9.9%) patients. Thus, this batch-based XHMM analysis efficiently selected rare pathogenic CNVs in genetic diseases.

Identifiants

pubmed: 33131168
doi: 10.1002/humu.24129
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

50-65

Informations de copyright

© 2020 Wiley Periodicals LLC.

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Auteurs

Yuri Uchiyama (Y)

Department of Rare Disease Genomics, Yokohama City University Hospital, Yokohama, Japan.
Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Kazuhiro Iwama (K)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Satoko Miyatake (S)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Clinical Genetics Department, Yokohama City University Hospital, Yokohama, Japan.

Kohei Hamanaka (K)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Naomi Tsuchida (N)

Department of Rare Disease Genomics, Yokohama City University Hospital, Yokohama, Japan.
Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Hiromi Aoi (H)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Department of Obstetrics and Gynecology, Faculty of Medicine Juntendo University, Tokyo, Japan.

Yoshiteru Azuma (Y)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Toshiyuki Itai (T)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Ken Saida (K)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Hiromi Fukuda (H)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Futoshi Sekiguchi (F)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Tomohiro Sakaguchi (T)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Ming Lei (M)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Sachiko Ohori (S)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Masamune Sakamoto (M)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Mitsuhiro Kato (M)

Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.

Takayoshi Koike (T)

National Epilepsy Center, NHO Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan.

Yukitoshi Takahashi (Y)

National Epilepsy Center, NHO Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan.

Koichi Tanda (K)

Department of Pediatrics, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan.

Yuki Hyodo (Y)

Department of Child Neurology, Okayama University Hospital, Okayama, Japan.

Rachel S Honjo (RS)

Unidade de Genetica do Instituto da Crianca do Hospital das Clinicas da Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

Debora Romeo Bertola (DR)

Unidade de Genetica do Instituto da Crianca do Hospital das Clinicas da Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

Chong Ae Kim (CA)

Unidade de Genetica do Instituto da Crianca do Hospital das Clinicas da Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

Masahide Goto (M)

Department of Pediatrics, Jichi Medical University, Shimotsuke, Japan.

Tetsuya Okazaki (T)

Department of Brain and Neurosciences, Division of Child Neurology, Faculty of Medicine, Tottori University, Yonago, Japan.

Hiroyuki Yamada (H)

Department of Brain and Neurosciences, Division of Child Neurology, Faculty of Medicine, Tottori University, Yonago, Japan.

Yoshihiro Maegaki (Y)

Department of Brain and Neurosciences, Division of Child Neurology, Faculty of Medicine, Tottori University, Yonago, Japan.

Hitoshi Osaka (H)

Department of Pediatrics, Jichi Medical University, Shimotsuke, Japan.

Lock-Hock Ngu (LH)

Department of Genetics, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia.

Ch'ng G Siew (CG)

Department of Genetics, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia.

Keng W Teik (KW)

Department of Genetics, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia.

Manami Akasaka (M)

Department of Pediatrics, Iwate Medical University School of Medicine, Morioka, Japan.

Hiroshi Doi (H)

Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Fumiaki Tanaka (F)

Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Tomohide Goto (T)

Division of Neurology, Kanagawa Children's Medical Center, Yokohama, Japan.

Long Guo (L)

Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.

Shiro Ikegawa (S)

Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.

Kazuhiro Haginoya (K)

Department of Pediatric Neurology, Miyagi Children's Hospital, Sendai, Japan.

Muzhirah Haniffa (M)

Department of Genetics, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia.

Nozomi Hiraishi (N)

Department of Pediatrics, Yokohama City University Medical Center, Yokohama, Japan.

Yoko Hiraki (Y)

Hiroshima Municipal Center for Child Health and Development, Hiroshima, Japan.

Satoru Ikemoto (S)

Division of Neurology, Saitama Children's Medical Center, Saitama, Japan.

Atsuro Daida (A)

Division of Neurology, Saitama Children's Medical Center, Saitama, Japan.

Shin-Ichiro Hamano (SI)

Division of Neurology, Saitama Children's Medical Center, Saitama, Japan.

Masaki Miura (M)

Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Department of Pediatrics, Nagaoka Red Cross Hospital, Nagaoka, Japan.

Akihiko Ishiyama (A)

Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.

Osamu Kawano (O)

Department of Pediatrics, Hokkaido University Hospital, Sapporo, Japan.

Akane Kondo (A)

Clinical Genetics Center, Shikoku Medical Center for Children and Adults, National Hospital Organization, Kagawa, Japan.

Hiroshi Matsumoto (H)

Department of Pediatrics, National Defense Medical College, Saitama, Japan.

Nobuhiko Okamoto (N)

Department of Medical Genetics, Osaka Women's and Children's Hospital, Osaka, Japan.

Tohru Okanishi (T)

Department of Brain and Neurosciences, Division of Child Neurology, Faculty of Medicine, Tottori University, Yonago, Japan.
Department of Child Neurology, Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.

Yukimi Oyoshi (Y)

Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.

Eri Takeshita (E)

Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.

Toshifumi Suzuki (T)

Department of Obstetrics and Gynecology, Faculty of Medicine Juntendo University, Tokyo, Japan.

Yoshiyuki Ogawa (Y)

Department of Hematology, Gunma University Graduate School of Medicine, Gunma, Japan.

Hiroshi Handa (H)

Department of Hematology, Gunma University Graduate School of Medicine, Gunma, Japan.

Yayoi Miyazono (Y)

Department of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Eriko Koshimizu (E)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Atsushi Fujita (A)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Atsushi Takata (A)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Noriko Miyake (N)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Takeshi Mizuguchi (T)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Naomichi Matsumoto (N)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

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