2-(2-Phenylethyl)chromone derivatives: Promising α-glucosidase inhibitors in agarwood from Aquilaria filaria.

Chromones / pharmacology Flavonoids Glycoside Hydrolase Inhibitors / pharmacology Molecular Structure Thymelaeaceae
2-(2-phenylethyl)chromone Agarwood Aquilaria filaria α-Glucosidase inhibitory activity

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
Jan 2021
Historique:
received: 30 08 2020
revised: 23 10 2020
accepted: 26 10 2020
pubmed: 11 11 2020
medline: 19 12 2020
entrez: 10 11 2020
Statut: ppublish

Résumé

Twelve undescribed 2-(2-phenylethyl)chromone derivatives, including one pair of enantiomers, together with eleven known ones, were isolated from the EtOAc extract of agarwood originating from Aquilaria filaria. All structures were elucidated by spectroscopic (NMR, UV, IR, MS) methods and compared with reported data in literatures. Twenty-one compounds were assessed for α-glucosidase inhibitory activity, which showed inhibition of α-glucosidase with IC

Identifiants

DOI: 10.1016/j.phytochem.2020.112578 PMID: 33171341
pubmed: 33171341
pii: S0031-9422(20)31193-6
doi: 10.1016/j.phytochem.2020.112578
pii:
doi:

Substances chimiques

Chromones 0
Flavonoids 0
Glycoside Hydrolase Inhibitors 0
2-(2-phenylethyl)chromone 61828-53-3

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

112578

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Cheng-Neng Mi (CN)

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, PR China; Institute of Tropical Agriculture and Forestry, Hainan University, Haikou, 570228, PR China; Hainan Engineering Research Center of Agarwood, 571101, Haikou, PR China.

Jing-Zhe Yuan (JZ)

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, PR China; Institute of Tropical Agriculture and Forestry, Hainan University, Haikou, 570228, PR China; Hainan Engineering Research Center of Agarwood, 571101, Haikou, PR China.

Man-Man Zhu (MM)

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, PR China; Hainan Engineering Research Center of Agarwood, 571101, Haikou, PR China.

Li Yang (L)

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, PR China; Hainan Engineering Research Center of Agarwood, 571101, Haikou, PR China.

Yan-Mei Wei (YM)

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, PR China; Hainan Engineering Research Center of Agarwood, 571101, Haikou, PR China.

Hao Wang (H)

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, PR China; Hainan Engineering Research Center of Agarwood, 571101, Haikou, PR China.

Wen-Xing Long (WX)

Institute of Tropical Agriculture and Forestry, Hainan University, Haikou, 570228, PR China.

Wen-Li Mei (WL)

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, PR China; Hainan Engineering Research Center of Agarwood, 571101, Haikou, PR China. Electronic address: meiwenli@itbb.org.cn.

Hao-Fu Dai (HF)

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, PR China; Institute of Tropical Agriculture and Forestry, Hainan University, Haikou, 570228, PR China; Hainan Engineering Research Center of Agarwood, 571101, Haikou, PR China. Electronic address: daihaofu@itbb.org.cnmailto.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › 2-(2-Phenylethyl)chromone derivatives:...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › 2-(2-Phenylethyl)chromone derivatives:...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Inhibiteurs des glycoside hydrolases › 2-(2-Phenylethyl)chromone derivatives:...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › 2-(2-Phenylethyl)chromone derivatives:...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Thymelaeaceae › 2-(2-Phenylethyl)chromone derivatives:...