Fusion genes as biomarkers in pediatric cancers: A review of the current state and applicability in diagnostics and personalized therapy.
Antineoplastic Agents
/ pharmacology
Biomarkers, Tumor
/ antagonists & inhibitors
Child
Circulating Tumor DNA
/ blood
Drug Monitoring
/ methods
Early Detection of Cancer
/ methods
Genetic Testing
/ methods
Genomics
/ methods
High-Throughput Nucleotide Sequencing
Humans
Liquid Biopsy
/ methods
Neoplasms
/ blood
Oncogene Proteins, Fusion
/ antagonists & inhibitors
Precision Medicine
/ methods
Treatment Outcome
Fusion genes
Next-generation sequencing
Pediatric cancer
ctDNA
Journal
Cancer letters
ISSN: 1872-7980
Titre abrégé: Cancer Lett
Pays: Ireland
ID NLM: 7600053
Informations de publication
Date de publication:
28 02 2021
28 02 2021
Historique:
received:
02
09
2020
revised:
09
11
2020
accepted:
11
11
2020
pubmed:
29
11
2020
medline:
21
5
2021
entrez:
28
11
2020
Statut:
ppublish
Résumé
The incidence of pediatric cancers is rising steadily across the world, along with the challenges in understanding the molecular mechanisms and devising effective therapeutic strategies. Pediatric cancers are presented with diverse molecular characteristics and more distinct subtypes when compared to adult cancers. Recent studies on the genomic landscape of pediatric cancers using next-generation sequencing (NGS) approaches have redefined this field by providing better subtype characterization and novel actionable targets. Since early identification and personalized treatment strategies influence therapeutic outcomes, survival, and quality of life in pediatric cancer patients, the quest for actionable biomarkers is of great value in this field. Fusion genes that are prevalent and recurrent in several pediatric cancers are ideally suited in this context due to their disease-specific occurrence. In this review, we explore the current status of fusion genes in pediatric cancer subtypes and their use as biomarkers for diagnosis and personalized therapy. We discuss the technological advancements made in recent years in NGS sequencing and their impact on fusion detection algorithms that have revolutionized this field. Finally, we also discuss the advantages of pairing liquid biopsy protocols for fusion detection and their eventual use in diagnosis and treatment monitoring.
Identifiants
pubmed: 33248210
pii: S0304-3835(20)30607-8
doi: 10.1016/j.canlet.2020.11.015
pmc: PMC9275405
mid: NIHMS1820076
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Biomarkers, Tumor
0
Circulating Tumor DNA
0
Oncogene Proteins, Fusion
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
24-38Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103427
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA036727
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM127200
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier B.V.
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