The combinatorial diversity of KIR and HLA class I allotypes in Peninsular Malaysia.
Alleles
Asian People
DNA Copy Number Variations
Female
Gene Frequency
Genetic Predisposition to Disease
Genetic Variation
Genotype
HLA-C Antigens
/ genetics
High-Throughput Nucleotide Sequencing
Humans
Incidence
Malaysia
/ epidemiology
Male
Native Hawaiian or Other Pacific Islander
Pre-Eclampsia
/ epidemiology
Pregnancy
Receptors, KIR2DL1
/ genetics
HLA
KIR
Malaysia
Natural killer (NK) cells
genetic diversity
Journal
Immunology
ISSN: 1365-2567
Titre abrégé: Immunology
Pays: England
ID NLM: 0374672
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
revised:
18
11
2020
received:
12
10
2020
accepted:
21
11
2020
pubmed:
8
12
2020
medline:
2
10
2021
entrez:
7
12
2020
Statut:
ppublish
Résumé
Killer cell immunoglobulin-like receptors (KIRs) interact with polymorphic human leucocyte antigen (HLA) class I molecules, modulating natural killer (NK) cell functions and affecting both the susceptibility and outcome of immune-mediated diseases. The KIR locus is highly diverse in gene content, copy number and allelic polymorphism within individuals and across geographical populations. To analyse currently under-represented Asian and Pacific populations, we investigated the combinatorial diversity of KIR and HLA class I in 92 unrelated Malay and 75 Malaysian Chinese individuals from the Malay Peninsula. We identified substantial allelic and structural diversity of the KIR locus in both populations and characterized novel variations at each analysis level. The Malay population is more diverse than Malay Chinese, likely representing a unique history including admixture with immigrating populations spanning several thousand years. Characterizing the Malay population are KIR haplotypes with large structural variants present in 10% individuals, and KIR and HLA alleles previously identified in Austronesian populations. Despite the differences in ancestries, the proportion of HLA allotypes that serve as KIR ligands is similar in each population. The exception is a significantly reduced frequency of interactions of KIR2DL1 with C2
Identifiants
pubmed: 33283280
doi: 10.1111/imm.13289
pmc: PMC7968402
doi:
Substances chimiques
HLA-C Antigens
0
KIR2DL1 protein, human
0
Receptors, KIR2DL1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
389-404Subventions
Organisme : NIAID NIH HHS
ID : R56 AI151549
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK116073
Pays : United States
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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