Genetic mechanisms of critical illness in COVID-19.
2',5'-Oligoadenylate Synthetase
/ genetics
COVID-19
/ genetics
Chromosomes, Human, Pair 12
/ genetics
Chromosomes, Human, Pair 19
/ genetics
Chromosomes, Human, Pair 21
/ genetics
Critical Care
Critical Illness
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
/ genetics
Drug Repositioning
Female
Genome-Wide Association Study
Humans
Inflammation
/ genetics
Lung
/ pathology
Male
Multigene Family
/ genetics
Receptor, Interferon alpha-beta
/ genetics
Receptors, CCR2
/ genetics
TYK2 Kinase
/ genetics
United Kingdom
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
27
09
2020
accepted:
30
11
2020
pubmed:
12
12
2020
medline:
9
3
2021
entrez:
11
12
2020
Statut:
ppublish
Résumé
Host-mediated lung inflammation is present
Identifiants
pubmed: 33307546
doi: 10.1038/s41586-020-03065-y
pii: 10.1038/s41586-020-03065-y
doi:
Substances chimiques
CCR2 protein, human
0
IFNAR2 protein, human
0
Receptors, CCR2
0
Receptor, Interferon alpha-beta
156986-95-7
TYK2 Kinase
EC 2.7.10.2
TYK2 protein, human
EC 2.7.10.2
OAS1 protein, human
EC 2.7.7.-
OAS2 protein, human
EC 2.7.7.-
2',5'-Oligoadenylate Synthetase
EC 2.7.7.84
OAS3 protein, human
EC 2.7.7.84
DPP9 protein, human
EC 3.4.14.-
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
EC 3.4.14.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
92-98Subventions
Organisme : Medical Research Council
ID : MR/K01417X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M00869X/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19056
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104036/Z/14/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1001253
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L501542/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R026408/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N02995X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_20004
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S006753/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 216767/Z/19/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0701075
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0901254
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19026
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_EX_MR/M009203/1
Pays : United Kingdom
Organisme : Parkinson's UK
ID : G-0907
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 205228/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 103258/Z/13/A
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19059
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00007/15
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12008/1
Pays : United Kingdom
Organisme : Parkinson's UK
ID : G-1307
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Organisme : Medical Research Council
ID : MC_UU_12014/9
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Organisme : Medical Research Council
ID : MR/S032304/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M009203/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J004758/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00007/10
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P015514/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19025
Pays : United Kingdom
Organisme : Wellcome Trust
ID : MR/R026408/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 215091/Z/18/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 109965/Z/15/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_14089
Pays : United Kingdom
Investigateurs
Johnny Millar
(J)
Alistair Nichol
(A)
Tim Walsh
(T)
Manu Shankar-Hari
(M)
Chris Ponting
(C)
Jen Meikle
(J)
Paul Finernan
(P)
Ellie Mcmaster
(E)
Andy Law
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J Kenneth Baillie
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Trevor Paterson
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Ruth Armstrong
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Tammy Gilchrist
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Katarzyna Hafezi
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Alan Maclean
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Sarah McCafferty
(S)
Kirstie Morrice
(K)
Jane Weaver
(J)
Ceilia Boz
(C)
Ailsa Golightly
(A)
Mari Ward
(M)
Hanning Mal
(H)
Helen Szoor-McElhinney
(H)
Adam Brown
(A)
Ross Hendry
(R)
Andrew Stenhouse
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Louise Cullum
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Dawn Law
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Sarah Law
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Maaike Swets
(M)
Nicky Day
(N)
Filip Taneski
(F)
Esther Duncan
(E)
Nicholas Parkinson
(N)
D Collier
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S Wood
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A Zak
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C Borra
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M Matharu
(M)
P May
(P)
Z Alldis
(Z)
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(O)
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A Easthope
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F Bibi
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M Patel
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M Taylor
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O Zongo
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P Harding
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M Burton
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T Newman
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C Tierney
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J Kassam
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M Shankar-Hari
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M Ostermann
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A Bociek
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N Grau
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T O Jones
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C Whitton
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M Marotti
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K Williams
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D Shaw
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J Fernandez Roman
(JF)
M Lopez Martinez
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A Waite
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B Johnston
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D Hamilton
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M Croft
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M Gellamucho
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R Griffiths
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P Bamford
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H Sainsbury
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R Jones
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G Bercades
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S Lee
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D Lomas
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M Slaughter
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J Dearden
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J Philbin
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C Rishton
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G O'Connor
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M Mulcahy
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E Dobson
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J Cuttler
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J Norris
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A Poole
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B Sloan
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S Buckley
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E Smithson
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R Charlesworth
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R Sandhu
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M Thirumaran
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V Wagstaff
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J Cebrian Suarez
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A Kaliappan
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M Vertue
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A Nicholson
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J Riches
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A Solesbury
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L Kittridge
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M Forsey
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G Maloney
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J Cole
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H Hill
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A Williams
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D Duffin
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B Player
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J Radhakrishnan
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S Gibson
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A Lyle
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F McNeela
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B Patel
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M Gummadi
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G Sloane
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N Dormand
(N)
S Salmi
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Z Farzad
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D Cristiano
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K Liyanage
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V Thwaites
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M Varghese
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M Meredith
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G Mills
(G)
J Willson
(J)
K Harrington
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B Lenagh
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K Cawthron
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S Masuko
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A Raithatha
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K Bauchmuller
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M Wiles
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N Ahmad
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J Barker
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Y Jackson
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F Kibutu
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S Bird
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G Watson
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J Martin
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E Bevan
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C Wrey Brown
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D Trodd
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K English
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G Bell
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L Wilcox
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A Katary
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S Gopal
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V Lake
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N Harris
(N)
S Metherell
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E Radford
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J Scriven
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F Moore
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H Bancroft
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J Daglish
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M Sangombe
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M Carmody
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J Rhodes
(J)
M Bellamy
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A Garg
(A)
A Kuravi
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E Virgilio
(E)
P Ranga
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J Butler
(J)
L Botfield
(L)
C Dexter
(C)
J Fletcher
(J)
P Shanmugasundaram
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G Hambrook
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I Burn
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K Manso
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D Thornton
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J Tebbutt
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R Penn
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(J)
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Z Maqsood
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(S)
J Colley
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A Hayes
(A)
C Ahmed
(C)
R Haq
(R)
S Clamp
(S)
R Kumar
(R)
M Purewal
(M)
B Baines
(B)
M Frise
(M)
N Jacques
(N)
H Coles
(H)
J Caterson
(J)
S Gurung Rai
(SG)
M Brunton
(M)
E Tilney
(E)
L Keating
(L)
A Walden
(A)
D Antcliffe
(D)
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(S)
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(A)
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(M)
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(D)
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(SS)
Z Fernandez
(Z)
P Coghlan
(P)
D Williams
(D)
C Jardine
(C)
J Bewley
(J)
K Sweet
(K)
L Grimmer
(L)
R Johnson
(R)
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(B)
C Phillips
(C)
L Ortiz-Ruiz de Gordoa
(L)
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(E)
A Tridente
(A)
K Shuker
(K)
S Greer
(S)
C Lynch
(C)
C Pothecary
(C)
L Roche
(L)
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(B)
K Turner
(K)
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(J)
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(GS)
P Paul
(P)
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(M)
I Wynter
(I)
V Ratnam
(V)
S Shelton
(S)
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(J)
J Melville
(J)
R Baruah
(R)
S Morrison
(S)
A McGregor
(A)
V Parris
(V)
M Mpelembue
(M)
S Srikaran
(S)
C Dennis
(C)
A Sukha
(A)
A Williams
(A)
M Verlander
(M)
K Holding
(K)
K Riches
(K)
C Downes
(C)
C Swan
(C)
A Rostron
(A)
A Roy
(A)
L Woods
(L)
S Cornell
(S)
F Wakinshaw
(F)
B Creagh-Brown
(B)
H Blackman
(H)
A Salberg
(A)
E Smith
(E)
S Donlon
(S)
S Mtuwa
(S)
N Michalak-Glinska
(N)
S Stone
(S)
C Beazley
(C)
V Pristopan
(V)
N Nikitas
(N)
L Lankester
(L)
C Wells
(C)
A S Raj
(AS)
K Fletcher
(K)
R Khade
(R)
G Tsinaslanidis
(G)
M MacMahon
(M)
S Fowler
(S)
A McGregor
(A)
T Coventry
(T)
R Stewart
(R)
L Wren
(L)
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(E)
L Mew
(L)
A Rose
(A)
D Scaletta
(D)
F Williams
(F)
K Inweregbu
(K)
A Nicholson
(A)
N Lancaster
(N)
M Cunningham
(M)
A Daniels
(A)
L Harrison
(L)
S Hope
(S)
S Jones
(S)
A Crew
(A)
G Wray
(G)
J Matthews
(J)
R Crawley
(R)
J Carter
(J)
I Birkinshaw
(I)
J Ingham
(J)
Z Scott
(Z)
H Pearson
(H)
K Howard
(K)
R Joy
(R)
S Roche
(S)
M Clark
(M)
S Purvis
(S)
A Morrison
(A)
D Strachan
(D)
M Taylor
(M)
S Clements
(S)
K Black
(K)
C Parmar
(C)
A Altabaibeh
(A)
K Simpson
(K)
L Mostoles
(L)
K Gilbert
(K)
L Ma
(L)
A Alvaro
(A)
M Thomas
(M)
B Faulkner
(B)
R Worner
(R)
K Hayes
(K)
E Gendall
(E)
H Blakemore
(H)
B Borislavova
(B)
E Goff
(E)
A Vuylsteke
(A)
L Mwaura
(L)
J Zamikula
(J)
L Garner
(L)
A Mitchell
(A)
S Mepham
(S)
L Cagova
(L)
A Fofano
(A)
H Holcombe
(H)
K Praman
(K)
T Szakmany
(T)
A E Heron
(AE)
S Cherian
(S)
S Cutler
(S)
A Roynon-Reed
(A)
G Randell
(G)
K Convery
(K)
K Stammers
(K)
D Fottrell-Gould
(D)
L Hudig
(L)
J Keshet-Price
(J)
M Peters
(M)
L O'Neill
(L)
S Ray
(S)
H Belfield
(H)
T McHugh
(T)
G Jones
(G)
O Akinkugbe
(O)
A Tomas
(A)
E Abaleke
(E)
E Beech
(E)
H Meghari
(H)
S Yussuf
(S)
A Bamford
(A)
B Hairsine
(B)
E Dooks
(E)
F Farquhar
(F)
S Packham
(S)
H Bates
(H)
C McParland
(C)
L Armstrong
(L)
C Kaye
(C)
A Allan
(A)
J Medhora
(J)
J Liew
(J)
A Botello
(A)
F Anderson
(F)
R Cusack
(R)
H Golding
(H)
K Prager
(K)
T Williams
(T)
S Leggett
(S)
K Golder
(K)
M Male
(M)
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Enrico Martinelli
(E)
Sandro Mancarella
(S)
Luisa Tavecchia
(L)
Lia Crotti
(L)
Nicola Picchiotti
(N)
Marco Gori
(M)
Chiara Gabbi
(C)
Maurizio Sanarico
(M)
Stefano Ceri
(S)
Pietro Pinoli
(P)
Francesco Raimondi
(F)
Filippo Biscarini
(F)
Alessandra Stella
(A)
Commentaires et corrections
Type : CommentIn
Références
Dorward, D. A. et al. Tissue-specific immunopathology in fatal COVID-19. Am. J. Respir. Crit. Care Med. https://doi.org/10.1164/rccm.202008-3265OC (2020).
The RECOVERY Collaborative Group. Dexamethasone in hospitalized patients with COVID-19 — preliminary report. N. Engl. J. Med. https://doi.org/10.1056/NEJMoa2021436 (2020).
Baillie, J. K. Targeting the host immune response to fight infection. Science 344, 807–808 (2014).
pubmed: 24855243
doi: 10.1126/science.1255074
Sørensen, T. I., Nielsen, G. G., Andersen, P. K. & Teasdale, T. W. Genetic and environmental influences on premature death in adult adoptees. N. Engl. J. Med. 318, 727–732 (1988).
pubmed: 3347221
doi: 10.1056/NEJM198803243181202
Patarčić, I. et al. The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis. Sci. Rep. 5, 16119 (2015).
pubmed: 26524966
pmcid: 4630784
doi: 10.1038/srep16119
Horby, P., Nguyen, N. Y., Dunstan, S. J. & Baillie, J. K. An updated systematic review of the role of host genetics in susceptibility to influenza. Influenza Other Respir. Viruses 7 (Suppl 2), 37–41 (2013).
pubmed: 24034482
pmcid: 5909389
doi: 10.1111/irv.12079
Clohisey, S. & Baillie, J. K. Host susceptibility to severe influenza A virus infection. Crit. Care 23, 303 (2019).
pubmed: 31488196
pmcid: 6729070
doi: 10.1186/s13054-019-2566-7
The Severe Covid-19 GWAS Group. Genomewide association study of severe COVID-19 with respiratory failure. N. Engl. J. Med. 383, 1522–1534 (2020).
doi: 10.1056/NEJMoa2020283
Shelton, J. F. et al. Trans-ethnic analysis reveals genetic and non-genetic associations with COVID-19 susceptibility and severity. Preprint at https://doi.org/10.1101/2020.09.04.20188318 (2020).
Casanova, J.-L. Severe infectious diseases of childhood as monogenic inborn errors of immunity. Proc. Natl Acad. Sci. USA 112, E7128–E7137 (2015).
pubmed: 26621750
doi: 10.1073/pnas.1521651112
pmcid: 4697435
Plenge, R. M. Molecular underpinnings of severe coronavirus disease 2019. J. Am. Med. Assoc. 324, 638–639 (2020).
doi: 10.1001/jama.2020.14015
Zhang, Q. et al. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science 370, eabd4570 (2020).
pubmed: 32972995
pmcid: 7857407
doi: 10.1126/science.abd4570
Millar, J. E. et al. Robust, reproducible clinical patterns in hospitalised patients with COVID-19. Preprint at https://doi.org/10.1101/2020.08.14.20168088 (2020).
Docherty, A. B. et al. Features of 20 133 UK patients in hospital with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. Br. Med. J. 369, m1985 (2020).
doi: 10.1136/bmj.m1985
Angus, D. C. et al. Effect of hydrocortisone on mortality and organ support in patients with severe COVID-19: the remap-cap COVID-19 corticosteroid domain randomized clinical trial. J. Am. Med. Assoc. 324, 1317–1329 (2020).
doi: 10.1001/jama.2020.17022
Carvelli, J. et al. Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis. Nature 588, 146–150 (2020).
pubmed: 32726800
doi: 10.1038/s41586-020-2600-6
pmcid: 7116884
Baillie, J. K. & Digard, P. Influenza — time to target the host? N. Engl. J. Med. 369, 191–193 (2013).
pubmed: 23841736
doi: 10.1056/NEJMcibr1304414
Bretherick, A. D. et al. Linking protein to phenotype with Mendelian randomization detects 38 proteins with causal roles in human diseases and traits. PLoS Genet. 16, e1008785 (2020).
pubmed: 32628676
pmcid: 7337286
doi: 10.1371/journal.pgen.1008785
Zhu, Z. et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat. Genet. 48, 481–487 (2016).
pubmed: 27019110
doi: 10.1038/ng.3538
Võsa, U. et al. Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis. Preprint at https://doi.org/10.1101/447367 (2018).
Gamazon, E. R. et al. A gene-based association method for mapping traits using reference transcriptome data. Nat. Genet. 47, 1091–1098 (2015).
pubmed: 26258848
pmcid: 4552594
doi: 10.1038/ng.3367
Gusev, A. et al. Integrative approaches for large-scale transcriptome-wide association studies. Nat. Genet. 48, 245–252 (2016).
pubmed: 26854917
pmcid: 4767558
doi: 10.1038/ng.3506
Barbeira, A. N. et al. Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics. Nat. Commun. 9, 1825 (2018).
pubmed: 29739930
pmcid: 5940825
doi: 10.1038/s41467-018-03621-1
Li, B. et al. Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection. Nat. Commun. 11, 164 (2020).
pubmed: 31919360
pmcid: 6952391
doi: 10.1038/s41467-019-13965-x
Ning, Z., Pawitan, Y. & Shen, X. High-definition likelihood inference of genetic correlations across human complex traits. Nat. Genet. 52, 859–864 (2020).
pubmed: 32601477
doi: 10.1038/s41588-020-0653-y
The FANTOM Consortium and the RIKEN PMI and CLST (DGT). A promoter-level mammalian expression atlas. Nature 507, 462–470 (2014).
doi: 10.1038/nature13182
Villar, D. et al. Enhancer evolution across 20 mammalian species. Cell 160, 554–566 (2015).
pubmed: 25635462
pmcid: 4313353
doi: 10.1016/j.cell.2015.01.006
Plenge, R. M., Scolnick, E. M. & Altshuler, D. Validating therapeutic targets through human genetics. Nat. Rev. Drug Discov. 12, 581–594 (2013).
pubmed: 23868113
doi: 10.1038/nrd4051
Davies, N. M., Holmes, M. V. & Davey Smith, G. Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. Br. Med. J. 362, k601 (2018).
doi: 10.1136/bmj.k601
Sadler, A. J. & Williams, B. R. G. Interferon-inducible antiviral effectors. Nat. Rev. Immunol. 8, 559–568 (2008).
pubmed: 18575461
pmcid: 2522268
doi: 10.1038/nri2314
Hambleton, S. et al. STAT2 deficiency and susceptibility to viral illness in humans. Proc. Natl Acad. Sci. USA 110, 3053–3058 (2013).
pubmed: 23391734
doi: 10.1073/pnas.1220098110
pmcid: 3581986
Duncan, C. J. A. et al. Human IFNAR2 deficiency: lessons for antiviral immunity. Sci. Transl. Med. 7, 307ra154 (2015).
pubmed: 26424569
pmcid: 4926955
doi: 10.1126/scitranslmed.aac4227
WHO Solidarity Trial Consortium. Repurposed antiviral drugs for COVID-19—interim WHO Solidarity trial results. N. Engl. J. Med. 384, 497–511 (2020).
Hamano, E. et al. Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population. Biochem. Biophys. Res. Commun. 329, 1234–1239 (2005).
pubmed: 15766558
pmcid: 7092916
doi: 10.1016/j.bbrc.2005.02.101
He, J. et al. Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes: a case–control study. BMC Infect. Dis. 6, 106 (2006).
pubmed: 16824203
pmcid: 1550407
doi: 10.1186/1471-2334-6-106
Choi, U. Y., Kang, J.-S., Hwang, Y. S. & Kim, Y.-J. Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases. Exp. Mol. Med. 47, e144 (2015).
pubmed: 25744296
pmcid: 4351405
doi: 10.1038/emm.2014.110
Hagemeijer, M. C., Vonk, A. M., Monastyrska, I., Rottier, P. J. M. & de Haan, C. A. Visualizing coronavirus RNA synthesis in time by using click chemistry. J. Virol. 86, 5808–5816 (2012).
pubmed: 22438542
pmcid: 3347275
doi: 10.1128/JVI.07207-11
Silverman, R. H. & Weiss, S. R. Viral phosphodiesterases that antagonize double-stranded RNA signaling to RNase L by degrading 2-5A. J. Interferon Cytokine Res. 34, 455–463 (2014).
pubmed: 24905202
pmcid: 4046343
doi: 10.1089/jir.2014.0007
Wood, E. R. et al. The role of phosphodiesterase 12 (PDE12) as a negative regulator of the innate immune response and the discovery of antiviral inhibitors. J. Biol. Chem. 290, 19681–19696 (2015).
pubmed: 26055709
pmcid: 4528132
doi: 10.1074/jbc.M115.653113
Fingerlin, T. E. et al. Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat. Genet. 45, 613–620 (2013).
pubmed: 23583980
pmcid: 3677861
doi: 10.1038/ng.2609
Zhang, H. et al. Identification of novel dipeptidyl peptidase 9 substrates by two-dimensional differential in-gel electrophoresis. FEBS J. 282, 3737–3757 (2015).
pubmed: 26175140
doi: 10.1111/febs.13371
Geiss-Friedlander, R. et al. The cytoplasmic peptidase DPP9 is rate-limiting for degradation of proline-containing peptides. J. Biol. Chem. 284, 27211–27219 (2009).
pubmed: 19667070
pmcid: 2785648
doi: 10.1074/jbc.M109.041871
Griswold, A. R. et al. DPP9’s enzymatic activity and not its binding to CARD8 inhibits inflammasome activation. ACS Chem. Biol. 14, 2424–2429 (2019).
pubmed: 31525884
pmcid: 6862324
doi: 10.1021/acschembio.9b00462
Nguyen, D.-T. et al. Pharos: collating protein information to shed light on the druggable genome. Nucleic Acids Res. 45 (D1), D995–D1002 (2017).
pubmed: 27903890
doi: 10.1093/nar/gkw1072
Parkinson, N. et al. Systematic review and meta-analysis identifies potential host therapeutic targets in COVID-19. Preprint at https://doi.org/10.1101/2020.08.27.20182238 (2020).
Zhou, Z. et al. Heightened innate immune responses in the respiratory tract of COVID-19 patients. Cell Host Microbe 27, 883–890 (2020).
pubmed: 32407669
pmcid: 7196896
doi: 10.1016/j.chom.2020.04.017
Zhao, Y. et al. Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease. JCI Insight 5, e139834 (2020).
pmcid: 7406242
doi: 10.1172/jci.insight.139834
Vergunst, C. E. et al. Modulation of CCR2 in rheumatoid arthritis: a double-blind, randomized, placebo-controlled clinical trial. Arthritis Rheum. 58, 1931–1939 (2008).
pubmed: 18576354
doi: 10.1002/art.23591
Sudlow, C. et al. UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 12, e1001779 (2015).
pubmed: 25826379
pmcid: 4380465
doi: 10.1371/journal.pmed.1001779
McKenna, A. et al. The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res. 20, 1297–1303 (2010).
pubmed: 20644199
pmcid: 2928508
doi: 10.1101/gr.107524.110
Meynert, A. M., Ansari, M., FitzPatrick, D. R. & Taylor, M. S. Variant detection sensitivity and biases in whole genome and exome sequencing. BMC Bioinformatics 15, 247 (2014).
pubmed: 25038816
pmcid: 4122774
doi: 10.1186/1471-2105-15-247
Guo, Y. et al. Illumina human exome genotyping array clustering and quality control. Nat. Protoc. 9, 2643–2662 (2014).
pubmed: 25321409
pmcid: 4441213
doi: 10.1038/nprot.2014.174
Gaziano, J. M. et al. Million Veteran Program: a mega-biobank to study genetic influences on health and disease. J. Clin. Epidemiol. 70, 214–223 (2016).
pubmed: 26441289
doi: 10.1016/j.jclinepi.2015.09.016
Manichaikul, A. et al. Robust relationship inference in genome-wide association studies. Bioinformatics 26, 2867–2873 (2010).
pubmed: 20926424
pmcid: 3025716
doi: 10.1093/bioinformatics/btq559
Yang, J., Lee, S. H., Goddard, M. E. & Visscher, P. M. GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet. 88, 76–82 (2011).
pubmed: 21167468
pmcid: 3014363
doi: 10.1016/j.ajhg.2010.11.011
Alexander, D. H. & Lange, K. Enhancements to the ADMIXTURE algorithm for individual ancestry estimation. BMC Bioinformatics 12, 246 (2011).
pubmed: 21682921
pmcid: 3146885
doi: 10.1186/1471-2105-12-246
Taliun, D. et al. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Preprint at https://doi.org/10.1101/563866 (2019).
Wigginton, J. E., Cutler, D. J. & Abecasis, G. R. A note on exact tests of Hardy–Weinberg equilibrium. Am. J. Hum. Genet. 76, 887–893 (2005).
pubmed: 15789306
pmcid: 1199378
doi: 10.1086/429864
Chang, C. C. et al. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience 4, 7 (2015).
pubmed: 25722852
pmcid: 4342193
doi: 10.1186/s13742-015-0047-8
Abraham, G., Qiu, Y. & Inouye, M. FlashPCA2: principal component analysis of Biobank-scale genotype datasets. Bioinformatics 33, 2776–2778 (2017).
pubmed: 28475694
doi: 10.1093/bioinformatics/btx299
Karczewski, K. J. et al. The mutational constraint spectrum quantified from variation in 141,456 humans. Nature 581, 434–443 (2020).
pubmed: 32461654
pmcid: 7334197
doi: 10.1038/s41586-020-2308-7
Willer, C. J., Li, Y. & Abecasis, G. R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190–2191 (2010).
pubmed: 20616382
pmcid: 2922887
doi: 10.1093/bioinformatics/btq340
Watanabe, K., Taskesen, E., van Bochoven, A. & Posthuma, D. Functional mapping and annotation of genetic associations with FUMA. Nat. Commun. 8, 1826 (2017).
pubmed: 29184056
pmcid: 5705698
doi: 10.1038/s41467-017-01261-5
Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559–575 (2007).
pubmed: 17701901
pmcid: 1950838
doi: 10.1086/519795
Smith, B. H. et al. Cohort Profile: Generation Scotland: Scottish Family Health Study (GS:SFHS). The study, its participants and their potential for genetic research on health and illness. Int. J. Epidemiol. 42, 689–700 (2013).
pubmed: 22786799
doi: 10.1093/ije/dys084
Amador, C. et al. Recent genomic heritage in Scotland. BMC Genomics 16, 437 (2015).
pubmed: 26048416
pmcid: 4458001
doi: 10.1186/s12864-015-1605-2
Nagy, R. et al. Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants. Genome Med. 9, 23 (2017).
pubmed: 28270201
pmcid: 5339960
doi: 10.1186/s13073-017-0414-4
Das, S. et al. Next-generation genotype imputation service and methods. Nat. Genet. 48, 1284–1287 (2016).
pubmed: 27571263
pmcid: 5157836
doi: 10.1038/ng.3656
Pasaniuc, B. et al. Fast and accurate imputation of summary statistics enhances evidence of functional enrichment. Bioinformatics 30, 2906–2914 (2014).
pubmed: 24990607
pmcid: 4184260
doi: 10.1093/bioinformatics/btu416
Barbeira, A. N. et al. Integrating predicted transcriptome from multiple tissues improves association detection. PLoS Genet. 15, e1007889 (2019).
pubmed: 30668570
pmcid: 6358100
doi: 10.1371/journal.pgen.1007889
GTEx Consortium. Genetic effects on gene expression across human tissues. Nature 550, 204–213 (2017).
pmcid: 5776756
doi: 10.1038/nature24277
Smith, B. H. et al. Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability. BMC Med. Genet. 7, 74 (2006).
pubmed: 17014726
pmcid: 1592477
doi: 10.1186/1471-2350-7-74
Zhu, Z. et al. Causal associations between risk factors and common diseases inferred from GWAS summary data. Nat. Commun. 9, 224 (2018).
pubmed: 29335400
pmcid: 5768719
doi: 10.1038/s41467-017-02317-2
de Leeuw, C. A., Mooij, J. M., Heskes, T. & Posthuma, D. MAGMA: generalized gene-set analysis of GWAS data. PLOS Comput. Biol. 11, e1004219 (2015).
pubmed: 25885710
pmcid: 4401657
doi: 10.1371/journal.pcbi.1004219
Finucane, H. K. et al. Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat. Genet. 47, 1228–1235 (2015).
pubmed: 26414678
pmcid: 4626285
doi: 10.1038/ng.3404
Bulik-Sullivan, B. et al. An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47, 1236–1241 (2015).
pubmed: 26414676
pmcid: 4797329
doi: 10.1038/ng.3406
Zheng, J. et al. LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis. Bioinformatics 33, 272–279 (2017).
pubmed: 27663502
doi: 10.1093/bioinformatics/btw613
Hinrichs, A. S. et al. The UCSC genome browser database: update 2006. Nucleic Acids Res. 34, D590–D598 (2006).
pubmed: 16381938
doi: 10.1093/nar/gkj144
Sun, J. et al. Comparative transcriptome analysis reveals the intensive early-stage responses of host cells to SARS-CoV-2 infection. Preprint at https://doi.org/10.1101/2020.04.30.071274 (2020).
Rosa, B. A. et al. IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection. Preprint at https://doi.org/10.1101/2020.08.06.239798 (2020).
Zhang, J.-Y. et al. Single-cell landscape of immunological responses in patients with COVID-19. Nat. Immunol. 21, 1107–1118 (2020).
pubmed: 32788748
doi: 10.1038/s41590-020-0762-x
Mick, E. et al. Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses. Nat. Commun. 11, 5854 (2020).
pubmed: 33203890
pmcid: 7673985
doi: 10.1038/s41467-020-19587-y
Wei, J. et al. Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection. Preprint at https://doi.org/10.1101/2020.06.16.155101 (2020).
Heaton, B. E. et al. SRSF protein kinases 1 and 2 are essential host factors for human coronaviruses including SARS-CoV-2. Preprint at https://doi.org/10.1101/2020.08.14.251207 (2020).
UK Data Service. 2011 Census Aggregate Data. https://doi.org/10.5257/census/aggregate-2011-2 (Office for National Statistics, National Records of Scotland, Northern Ireland Statistics and Research Agency, 2017).