Chromatin Regulation through Ubiquitin and Ubiquitin-like Histone Modifications.
DNA methylation
epigenetics
histones
phase separation
post-translational modifications
ubiquitin-like modifications
ubiquitination
Journal
Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
18
08
2020
revised:
27
10
2020
accepted:
09
11
2020
pubmed:
15
12
2020
medline:
18
9
2021
entrez:
14
12
2020
Statut:
ppublish
Résumé
Chromatin functions are influenced by the addition, removal, and recognition of histone post-translational modifications (PTMs). Ubiquitin and ubiquitin-like (UBL) PTMs on histone proteins can function as signaling molecules by mediating protein-protein interactions. Fueled by the identification of novel ubiquitin and UBL sites and the characterization of the writers, erasers, and readers, the breadth of chromatin functions associated with ubiquitin signaling is emerging. Here, we highlight recently appreciated roles for histone ubiquitination in DNA methylation control, PTM crosstalk, nucleosome structure, and phase separation. We also discuss the expanding diversity and functions associated with histone UBL modifications. We conclude with a look toward the future and pose key questions that will drive continued discovery at the interface of epigenetics and ubiquitin signaling.
Identifiants
pubmed: 33308996
pii: S0968-0004(20)30276-0
doi: 10.1016/j.tibs.2020.11.005
pmc: PMC7954875
mid: NIHMS1646775
pii:
doi:
Substances chimiques
Chromatin
0
Histones
0
Ubiquitin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
258-269Subventions
Organisme : NCI NIH HHS
ID : F99 CA245821
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM124736
Pays : United States
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Références
Nucleic Acids Res. 1980 Oct 24;8(20):4671-80
pubmed: 6255427
Open Biol. 2016 Jun;6(6):
pubmed: 27335322
Cell Res. 2015 Aug;25(8):911-29
pubmed: 26065575
Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8775-8780
pubmed: 30104358
Cell Res. 2019 Apr;29(4):330-333
pubmed: 30770869
Mol Cell. 2012 Nov 30;48(4):572-86
pubmed: 23063525
Nucleic Acids Res. 2018 May 18;46(9):4405-4416
pubmed: 29506131
Mol Cell. 2019 Dec 5;76(5):712-723.e4
pubmed: 31733991
Epigenetics Chromatin. 2019 Aug 21;12(1):52
pubmed: 31434570
Cell Cycle. 2012 Apr 15;11(8):1573-82
pubmed: 22456334
Cell Death Dis. 2015 Apr 09;6:e1716
pubmed: 25855964
Nat Commun. 2019 Aug 22;10(1):3795
pubmed: 31439846
EMBO Rep. 2014 Sep;15(9):956-64
pubmed: 25092792
Cell. 2019 Mar 7;176(6):1490-1501.e12
pubmed: 30765112
DNA Repair (Amst). 2015 Dec;36:36-42
pubmed: 26422137
Science. 2016 Feb 12;351(6274):725-8
pubmed: 26912860
Nature. 2017 Oct 26;550(7677):481-486
pubmed: 29045389
Nat Commun. 2017 Jan 30;8:14286
pubmed: 28134249
Nucleic Acids Res. 2011 Oct;39(19):8355-65
pubmed: 21745816
Cell. 2006 May 5;125(3):483-95
pubmed: 16603237
Mol Cell. 2018 Mar 15;69(6):965-978.e6
pubmed: 29526694
J Cell Sci. 2012 Oct 1;125(Pt 19):4576-85
pubmed: 22797925
J Biol Chem. 1988 Sep 15;263(26):13268-75
pubmed: 2843516
Nature. 2020 Jan;577(7792):717-720
pubmed: 31969703
Mol Cell. 2018 Oct 4;72(1):19-36.e8
pubmed: 30244836
Nature. 2017 Oct 26;550(7677):534-538
pubmed: 29045385
Sci Rep. 2017 Dec;7(1):55
pubmed: 28246399
Mol Cell. 2017 Oct 19;68(2):350-360.e7
pubmed: 29053958
Annu Rev Biochem. 2012;81:203-29
pubmed: 22524316
J Biol Chem. 2010 Nov 19;285(47):36377-86
pubmed: 20847044
Cell Res. 2016 Apr;26(4):484-98
pubmed: 27002218
Proc Natl Acad Sci U S A. 1977 Mar;74(3):864-8
pubmed: 265581
Nat Struct Mol Biol. 2012 Dec;19(12):1266-72
pubmed: 23142980
Nat Commun. 2017 Mar 16;8:14799
pubmed: 28300060
Mol Cell. 2017 May 18;66(4):473-487.e9
pubmed: 28506460
Nat Rev Immunol. 2019 Jul;19(7):417-432
pubmed: 30918351
Elife. 2016 Sep 06;5:
pubmed: 27595565
Cell. 2016 Jul 28;166(3):651-663
pubmed: 27374333
Elife. 2020 Jan 10;9:
pubmed: 31922488
J Proteome Res. 2014 Jan 3;13(1):268-76
pubmed: 23862649
PLoS One. 2016 Jun 01;11(6):e0156718
pubmed: 27249653
Nat Commun. 2016 Apr 05;7:11197
pubmed: 27045799
Epigenetics Chromatin. 2020 Jan 24;13(1):3
pubmed: 31980037
Cell Rep. 2019 Feb 12;26(7):1681-1690.e5
pubmed: 30759380
Cell. 2016 Mar 24;165(1):248-248.e1
pubmed: 27015313
Nature. 2016 Aug 4;536(7614):100-3
pubmed: 27462807
Nat Commun. 2019 Nov 26;10(1):5383
pubmed: 31772204
Nat Commun. 2018 Aug 20;9(1):3321
pubmed: 30127417
Nature. 2013 Oct 10;502(7470):249-53
pubmed: 24013172
Mol Cell. 2011 Jul 8;43(1):85-96
pubmed: 21726812
Elife. 2018 Aug 06;7:
pubmed: 30079888
Cell Chem Biol. 2017 Jan 19;24(1):9-23
pubmed: 27989401
Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18439-18447
pubmed: 32675241
Nucleic Acids Res. 2018 Jul 27;46(13):6608-6626
pubmed: 29846670
Mol Cell. 2011 Jul 8;43(1):132-44
pubmed: 21726816
Protein Sci. 2006 Mar;15(3):647-54
pubmed: 16501229
J Cell Sci. 2014 May 15;127(Pt 10):2238-48
pubmed: 24634510
Blood Cancer J. 2017 Feb 17;7(2):e527
pubmed: 28211885
Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1299-1308
pubmed: 30626644
Nature. 2020 Mar;579(7800):592-597
pubmed: 32214243
Genes Dev. 2019 Jun 1;33(11-12):620-625
pubmed: 30923167
Mol Cell. 2018 Nov 15;72(4):753-765.e6
pubmed: 30392931
Life Sci Alliance. 2018 Jun 21;1(3):e201800096
pubmed: 30456359
Nature. 2016 Jun 30;534(7609):714-718
pubmed: 27338793
Nucleic Acids Res. 2019 Sep 26;47(17):9053-9068
pubmed: 31400111
J Biol Chem. 2019 Oct 18;294(42):15218-15234
pubmed: 31285264
EMBO Rep. 2014 May;15(5):601-8
pubmed: 24714598
EMBO J. 2016 Jun 15;35(12):1254-75
pubmed: 27220849
Mol Cell. 2011 Aug 5;43(3):392-405
pubmed: 21816346
Proc Natl Acad Sci U S A. 1975 Jan;72(1):11-5
pubmed: 1078892
Cell Commun Signal. 2016 Jan 05;14:1
pubmed: 26727894
ACS Chem Biol. 2019 Oct 18;14(10):2315-2326
pubmed: 31479228
Nat Commun. 2020 Mar 6;11(1):1222
pubmed: 32144273
J Biol Chem. 1975 Sep 25;250(18):7182-7
pubmed: 1165239
Nature. 2000 Jan 6;403(6765):41-5
pubmed: 10638745
PLoS One. 2020 Apr 16;15(4):e0231223
pubmed: 32298286
Mol Cell. 2013 Mar 7;49(5):897-907
pubmed: 23394999
Nat Med. 2018 Feb;24(2):186-193
pubmed: 29334375
J Exp Med. 2017 Jun 5;214(6):1843-1855
pubmed: 28507061
J Biol Chem. 2014 Dec 5;289(49):33827-37
pubmed: 25294883
Nature. 2019 Sep;573(7774):445-449
pubmed: 31485071
Biochem Biophys Res Commun. 2013 Jun 28;436(2):240-5
pubmed: 23726919
Sci Rep. 2020 Mar 24;10(1):5324
pubmed: 32210275
Biomol Concepts. 2016 Aug 1;7(4):215-27
pubmed: 27522625
Nature. 2020 Feb;578(7794):296-300
pubmed: 32025036
Nat Commun. 2018 Apr 24;9(1):1641
pubmed: 29691401
Cell Discov. 2020 Aug 24;6:58
pubmed: 32884836
Genes Dev. 2019 Dec 1;33(23-24):1751-1774
pubmed: 31753913
Nat Med. 2000 Oct;6(10):1073-81
pubmed: 11017125
Mol Cell. 2018 Nov 15;72(4):739-752.e9
pubmed: 30392929
DNA Repair (Amst). 2017 Aug;56:92-101
pubmed: 28624371
Nat Commun. 2019 Mar 18;10(1):1242
pubmed: 30886146
Nat Cell Biol. 2019 Mar;21(3):311-318
pubmed: 30804502
J Cell Sci. 2003 Feb 15;116(Pt 4):605-16
pubmed: 12538761
Mol Cell. 2008 Jan 18;29(1):69-80
pubmed: 18206970
Elife. 2018 Jul 25;7:
pubmed: 30044219
Cancer Res. 2020 Aug 1;80(15):3074-3087
pubmed: 32522824
Nat Commun. 2015 May 11;6:7023
pubmed: 25960197
Chembiochem. 2017 Jan 17;18(2):176-180
pubmed: 27976477