Attenuation of SRC Kinase Activity Augments PARP Inhibitor-mediated Synthetic Lethality in
Animals
Antineoplastic Agents
/ pharmacology
Apoptosis
BRCA2 Protein
/ genetics
Cell Proliferation
Drug Synergism
Drug Therapy, Combination
Gene Expression Regulation, Neoplastic
/ drug effects
Humans
Male
Mice
Mice, Nude
Poly(ADP-ribose) Polymerase Inhibitors
/ pharmacology
Prognosis
Prostatic Neoplasms, Castration-Resistant
/ drug therapy
Survival Rate
Synthetic Lethal Mutations
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
src-Family Kinases
/ antagonists & inhibitors
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 03 2021
15 03 2021
Historique:
received:
29
06
2020
revised:
04
11
2020
accepted:
14
12
2020
pubmed:
19
12
2020
medline:
8
2
2022
entrez:
18
12
2020
Statut:
ppublish
Résumé
Alterations in DNA damage repair (DDR) pathway genes occur in 20%-25% of men with metastatic castration-resistant prostate cancer (mCRPC). Although PARP inhibitors (PARPis) have been shown to benefit men with mCRPC harboring DDR defects due to mutations in We performed transcriptomic analysis of publicly available mCRPC cases, comparing We observed significant enrichment of the SRC signaling pathway in This work suggests that SRC activation may be a potential mechanism of PARPi resistance and that treatment with SRC inhibitors may overcome this resistance. Our preclinical study demonstrates that combining PARPis and SRC inhibitors may be a promising therapeutic strategy for patients with
Identifiants
pubmed: 33334906
pii: 1078-0432.CCR-20-2483
doi: 10.1158/1078-0432.CCR-20-2483
pmc: PMC7956224
mid: NIHMS1656559
doi:
Substances chimiques
Antineoplastic Agents
0
BRCA2 Protein
0
BRCA2 protein, human
0
Poly(ADP-ribose) Polymerase Inhibitors
0
src-Family Kinases
EC 2.7.10.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1792-1806Subventions
Organisme : NCI NIH HHS
ID : P01 CA228696
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
Références
Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15541-6
pubmed: 18840695
J Clin Oncol. 2019 Feb 20;37(6):490-503
pubmed: 30625039
Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11428-11436
pubmed: 31061129
Trends Pharmacol Sci. 2012 Mar;33(3):122-8
pubmed: 22153719
Cell Cycle. 2015;14(21):3389-95
pubmed: 26566862
Mol Cell Biol. 2004 Sep;24(18):8113-33
pubmed: 15340073
J Exp Clin Cancer Res. 2018 Jul 16;37(1):153
pubmed: 30012171
Mol Cell Biol. 1989 Sep;9(9):3647-56
pubmed: 2476663
Cell. 2016 Aug 11;166(4):1041-1054
pubmed: 27499020
J Clin Oncol. 2013 May 10;31(14):1748-57
pubmed: 23569316
Cell. 2014 Sep 25;159(1):176-187
pubmed: 25201530
Nature. 2012 Mar 28;483(7391):603-7
pubmed: 22460905
Nat Med. 2016 Apr;22(4):369-78
pubmed: 26928463
Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1643-8
pubmed: 22307624
Science. 2017 Mar 17;355(6330):1152-1158
pubmed: 28302823
Biochem Biophys Res Commun. 2006 Mar 10;341(2):363-8
pubmed: 16414009
J Signal Transduct. 2011;2011:865819
pubmed: 21776389
Cancer Res. 2005 Oct 15;65(20):9185-9
pubmed: 16230377
Cancer Res. 1997 Aug 15;57(16):3325-30
pubmed: 9269988
Curr Opin Genet Dev. 2019 Feb;54:55-63
pubmed: 30954761
J Am Acad Dermatol. 2012 Feb;66(2):e47-53
pubmed: 21620517
J Clin Oncol. 2009 Apr 20;27(12):2022-9
pubmed: 19289629
Nat Rev Cancer. 2016 Jan;16(1):35-42
pubmed: 26667849
BJU Int. 2009 Feb;103(4):434-40
pubmed: 19154462
Cancer Cell. 2009 Jul 7;16(1):67-78
pubmed: 19573813
Mol Cancer Res. 2014 Oct;12(10):1470-9
pubmed: 25053806
J Clin Oncol. 2017 Jul 1;35(19):2193-2202
pubmed: 28471727
Ann Oncol. 2019 Sep 1;30(9):1437-1447
pubmed: 31218365
DNA Repair (Amst). 2018 Nov;71:172-176
pubmed: 30177437
Nat Rev Mol Cell Biol. 2017 Aug;18(8):495-506
pubmed: 28512351
J Biol Chem. 2014 May 2;289(18):12313-29
pubmed: 24634213
Ther Adv Med Oncol. 2020 Mar 18;12:1758835919897537
pubmed: 32215055
Blood. 2003 Aug 15;102(4):1515-24
pubmed: 12689930
Mol Cancer Ther. 2010 May;9(5):1147-57
pubmed: 20423991
Cancer Discov. 2012 May;2(5):401-4
pubmed: 22588877
Lancet Oncol. 2013 Dec;14(13):1307-16
pubmed: 24211163
Cell Rep. 2018 Apr 03;23(1):239-254.e6
pubmed: 29617664
Nature. 2019 Jul;571(7766):576-579
pubmed: 31292550
Adv Exp Med Biol. 2019;1210:279-300
pubmed: 31900913
Cancer Cell. 2008 Aug 12;14(2):166-79
pubmed: 18691551
Trends Genet. 2014 Aug;30(8):326-39
pubmed: 25017190
Nat Rev Cancer. 2018 Jul;18(7):407-418
pubmed: 29692415
Clin Cancer Res. 2009 May 15;15(10):3540-9
pubmed: 19447874
Cell Biol Int. 2016 Jan;40(1):16-26
pubmed: 26194897
Clin Cancer Res. 2020 Jun 1;26(11):2487-2496
pubmed: 32086346
Clin Cancer Res. 2020 Apr 15;26(8):2047-2064
pubmed: 31796516
J Clin Invest. 2020 Apr 1;130(4):1653-1668
pubmed: 32091413
Nat Genet. 2018 May;50(5):645-651
pubmed: 29610475
Carcinogenesis. 1997 Jun;18(6):1215-23
pubmed: 9214605
Cancer Res. 2010 Jan 15;70(2):440-6
pubmed: 20068163
JCO Precis Oncol. 2020;4:355-366
pubmed: 32856010
Nature. 2001 May 17;411(6835):366-74
pubmed: 11357144
Mol Cell Biol. 2010 Sep;30(17):4094-107
pubmed: 20584982
Cell. 2016 Jun 30;166(1):47-62
pubmed: 27368100
Sci Signal. 2013 Apr 02;6(269):pl1
pubmed: 23550210
Mol Cancer Res. 2015 Feb;13(2):339-47
pubmed: 25298407
N Engl J Med. 2020 May 28;382(22):2091-2102
pubmed: 32343890
Mol Cancer Ther. 2010 Jun;9(6):1629-37
pubmed: 20484016
Cancer Res. 2013 Jan 15;73(2):978-89
pubmed: 23204233
N Engl J Med. 2015 Oct 29;373(18):1697-708
pubmed: 26510020
Oncotarget. 2017 Feb 7;8(6):10324-10347
pubmed: 28055971
Urol Oncol. 2017 Aug;35(8):535
pubmed: 28623072
Exp Mol Med. 2012 Jan 31;44(1):10-9
pubmed: 22217448
N Engl J Med. 2016 Aug 4;375(5):443-53
pubmed: 27433846
Asian J Urol. 2019 Jan;6(1):26-41
pubmed: 30775246
Nucleic Acids Res. 2009 Jul;37(Web Server issue):W305-11
pubmed: 19465376
Front Oncol. 2014 Aug 18;4:222
pubmed: 25184116