Comparative genomics reveals dynamic genome evolution in host specialist ectomycorrhizal fungi.
Suillus
G-protein coupled receptors
genomics
host specificity
secondary metabolites
small secreted proteins
Journal
The New phytologist
ISSN: 1469-8137
Titre abrégé: New Phytol
Pays: England
ID NLM: 9882884
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
19
10
2020
accepted:
16
12
2020
pubmed:
29
12
2020
medline:
15
5
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
While there has been significant progress characterizing the 'symbiotic toolkit' of ectomycorrhizal (ECM) fungi, how host specificity may be encoded into ECM fungal genomes remains poorly understood. We conducted a comparative genomic analysis of ECM fungal host specialists and generalists, focusing on the specialist genus Suillus. Global analyses of genome dynamics across 46 species were assessed, along with targeted analyses of three classes of molecules previously identified as important determinants of host specificity: small secreted proteins (SSPs), secondary metabolites (SMs) and G-protein coupled receptors (GPCRs). Relative to other ECM fungi, including other host specialists, Suillus had highly dynamic genomes including numerous rapidly evolving gene families and many domain expansions and contractions. Targeted analyses supported a role for SMs but not SSPs or GPCRs in Suillus host specificity. Phylogenomic-based ancestral state reconstruction identified Larix as the ancestral host of Suillus, with multiple independent switches between white and red pine hosts. These results suggest that like other defining characteristics of the ECM lifestyle, host specificity is a dynamic process at the genome level. In the case of Suillus, both SMs and pathways involved in the deactivation of reactive oxygen species appear to be strongly associated with enhanced host specificity.
Identifiants
pubmed: 33355923
doi: 10.1111/nph.17160
pmc: PMC7969408
mid: NIHMS1657233
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
774-792Subventions
Organisme : NIH HHS
ID : S10 OD016290
Pays : United States
Informations de copyright
© 2020 The Authors. New Phytologist © 2020 New Phytologist Foundation.
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