Molecular Mechanisms of Colon Cancer Progression and Metastasis: Recent Insights and Advancements.
Adenomatous Polyposis Coli Protein
/ genetics
Animals
Cell Movement
/ physiology
Chromosomal Instability
Chromosomes, Human, Pair 18
Colon
/ pathology
Colorectal Neoplasms
/ metabolism
CpG Islands
Disease Progression
ErbB Receptors
/ metabolism
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Loss of Heterozygosity
Microsatellite Repeats
Neoplasm Metastasis
Phenotype
Proto-Oncogene Proteins B-raf
/ metabolism
Proto-Oncogene Proteins p21(ras)
/ metabolism
Risk
Signal Transduction
Tumor Suppressor Protein p53
/ metabolism
Wnt Proteins
/ metabolism
Wnt Signaling Pathway
/ physiology
beta Catenin
/ metabolism
Colorectal cancer
chromosomal instability
microsatellite instability
molecular pathways
therapeutics
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Dec 2020
24 Dec 2020
Historique:
received:
21
11
2020
revised:
09
12
2020
accepted:
10
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
14
9
2021
Statut:
epublish
Résumé
Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause of cancer-related mortality rates worldwide. Although modern research was able to shed light on the pathogenesis of CRC and provide enhanced screening strategies, the prevalence of CRC is still on the rise. Studies showed several cellular signaling pathways dysregulated in CRC, leading to the onset of malignant phenotypes. Therefore, analyzing signaling pathways involved in CRC metastasis is necessary to elucidate the underlying mechanism of CRC progression and pharmacotherapy. This review focused on target genes as well as various cellular signaling pathways including Wnt/β-catenin, p53, TGF-β/SMAD, NF-κB, Notch, VEGF, and JAKs/STAT3, which are associated with CRC progression and metastasis. Additionally, alternations in methylation patterns in relation with signaling pathways involved in regulating various cellular mechanisms such as cell cycle, transcription, apoptosis, and angiogenesis as well as invasion and metastasis were also reviewed. To date, understanding the genomic and epigenomic instability has identified candidate biomarkers that are validated for routine clinical use in CRC management. Nevertheless, better understanding of the onset and progression of CRC can aid in the development of early detection molecular markers and risk stratification methods to improve the clinical care of CRC patients.
Identifiants
pubmed: 33374459
pii: ijms22010130
doi: 10.3390/ijms22010130
pmc: PMC7794761
pii:
doi:
Substances chimiques
APC protein, human
0
Adenomatous Polyposis Coli Protein
0
CTNNB1 protein, human
0
KRAS protein, human
0
TP53 protein, human
0
Tumor Suppressor Protein p53
0
Wnt Proteins
0
beta Catenin
0
ErbB Receptors
EC 2.7.10.1
BRAF protein, human
EC 2.7.11.1
Proto-Oncogene Proteins B-raf
EC 2.7.11.1
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Qatar University
ID : QUHI-CMED-19/20-1 and QUCG-CMED-20/21-2
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