Synthesis of benzimidazole based hydrazones as non-sugar based α-glucosidase inhibitors: Structure activity relation and molecular docking.
X-ray crystallography
benzimidazole based hydrazones
diabetes mellitus
molecular docking studies
α-glucosidase inhibitor
Journal
Drug development research
ISSN: 1098-2299
Titre abrégé: Drug Dev Res
Pays: United States
ID NLM: 8204468
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
09
02
2021
received:
10
01
2021
accepted:
18
02
2021
pubmed:
6
3
2021
medline:
5
4
2022
entrez:
5
3
2021
Statut:
ppublish
Résumé
In search for α-glucosidase inhibitors used in the treatment of diabetes mellitus, a series of unique benzimidazole based hydrazones derivatives were synthesized (5a-5p), which were then investigated for their in vitro α-glucosidase inhibitory potential. The compounds of interest were characterized by modern spectroscopic approaches including CHN,
Substances chimiques
Benzimidazoles
0
Glycoside Hydrolase Inhibitors
0
Hydrazones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1033-1043Informations de copyright
© 2021 Wiley Periodicals LLC.
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