Differential Function of a Novel Population of the CD19+CD24hiCD38hi Bregs in Psoriasis and Multiple Myeloma.
ADP-ribosyl Cyclase 1
/ metabolism
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal
/ pharmacology
Antigens, CD19
/ metabolism
B-Lymphocytes, Regulatory
/ drug effects
CD24 Antigen
/ metabolism
Female
Humans
Interleukin-10
/ blood
Leukocytes, Mononuclear
/ drug effects
Male
Middle Aged
Multiple Myeloma
/ blood
Multiple Sclerosis, Relapsing-Remitting
/ blood
Psoriasis
/ blood
Young Adult
Bregs
interleukin 10
multiple myeloma
psoriasis
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
16 02 2021
16 02 2021
Historique:
received:
29
12
2020
revised:
11
02
2021
accepted:
13
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
27
8
2021
Statut:
epublish
Résumé
Psoriasis (Ps), an autoimmune disease, and multiple myeloma (MM), a blood neoplasm, are characterized by immune dysregulation resulting from the imbalance between the effector and regulatory cells, including B regulatory (Breg) lymphocytes. Peripheral blood samples from 80 Ps patients, 17 relapsed/refractory MM patients before and after daratumumab (anti-CD38 monoclonal antibody) treatment, 23 healthy volunteers (HVs), and bone marrow samples from 59 MM patients were used in the study. Bregs were determined by flow cytometry using CD19, CD24, and CD38. Intracellular production of interleukin-10 (IL-10) was assessed by flow cytometry after CD40L, LPS, and CpG stimulation. IL-10 serum or plasma concentrations were tested using ELISA method. The percentage of CD19+CD24hiCD38hi Bregs was not different whereas the production of IL-10 in Bregs was significantly higher in Ps patients in comparison with HVs. The percentage of CD19+CD24hiCD38hi Bregs in MM patients was significantly higher than in HVs (
Identifiants
pubmed: 33669402
pii: cells10020411
doi: 10.3390/cells10020411
pmc: PMC7920433
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antigens, CD19
0
CD24 Antigen
0
IL10 protein, human
0
Interleukin-10
130068-27-8
daratumumab
4Z63YK6E0E
ADP-ribosyl Cyclase 1
EC 3.2.2.6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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