Androgen receptor CAG repeat length as a moderator of the relationship between free testosterone levels and cognition.

Aged Australia Cognition Humans Male Receptors, Androgen / genetics Testosterone Trinucleotide Repeats / genetics
Alzheimer's disease Androgen receptor Attention Cognition Executive function Language Memory Processing speed Testosterone

Journal

Hormones and behavior
ISSN: 1095-6867
Titre abrégé: Horm Behav
Pays: United States
ID NLM: 0217764

Informations de publication

Date de publication:
05 2021
Historique:
received: 17 07 2020
revised: 19 02 2021
accepted: 22 02 2021
pubmed: 15 3 2021
medline: 3 11 2021
entrez: 14 3 2021
Statut: ppublish

Résumé

Age-related decrease in testosterone levels is a potential risk factor for cognitive decline in older men. However, observational studies and clinical trials have reported inconsistent results on the effects of testosterone on individual cognitive domains. Null findings may be attributed to factors that studies have yet to consider. In particular, individual variations in polyglutamine (CAG) length in the androgen receptor (AR) gene could alter androgenic activity in brain regions associated with cognitive processes including memory and executive functions. However, the role of AR CAG repeat length as a moderator of the relationship between testosterone levels and cognition has not been investigated. Therefore, we aimed to examine the relationship between baseline calculated free testosterone (cFT) levels, change in cFT levels over 18 months and CAG repeat length on cognitive performance in memory, executive function, language, attention and processing speed domains. These relationships were examined in 304 cognitively normal older male participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing. In the attention and processing speed domain, a short CAG repeat length appears to exacerbate the effects of low baseline cFT levels that are also lower than expected at follow-up. These results highlight that individual variations in AR CAG repeat length should be considered in future studies and clinical trials that examine the complex relationship between testosterone and cognition.

Identifiants

DOI: 10.1016/j.yhbeh.2021.104966 PMID: 33714752
pubmed: 33714752
pii: S0018-506X(21)00045-3
doi: 10.1016/j.yhbeh.2021.104966
pii:
doi:

Substances chimiques

Receptors, Androgen 0
Testosterone 3XMK78S47O

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

104966

Informations de copyright

Crown Copyright © 2021. Published by Elsevier Inc. All rights reserved.

Auteurs

Sherilyn Tan (S)

Australian Alzheimer's Research Foundation, Ralph and Patricia Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia; School of Psychological Science, University of Western Australia, Nedlands, Western Australia, Australia.

Tenielle Porter (T)

Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia.

Romola S Bucks (RS)

School of Psychological Science, University of Western Australia, Nedlands, Western Australia, Australia.

Michael Weinborn (M)

Australian Alzheimer's Research Foundation, Ralph and Patricia Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia; School of Psychological Science, University of Western Australia, Nedlands, Western Australia, Australia.

Lidija Milicic (L)

Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia.

Ailsa Brown (A)

Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.

Stephanie R Rainey-Smith (SR)

Australian Alzheimer's Research Foundation, Ralph and Patricia Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia; School of Psychological Science, University of Western Australia, Nedlands, Western Australia, Australia; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.

Kevin Taddei (K)

Australian Alzheimer's Research Foundation, Ralph and Patricia Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.

David Ames (D)

Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia; University of Melbourne Academic Unit for Psychiatry of Old Age, Parkville, Victoria, Australia; National Ageing Research Institute (NARI), Parkville, Victoria, Australia.

Colin L Masters (CL)

Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia; Cooperative Research Centre for Mental Health, Carlton, Victoria, Australia.

Paul Maruff (P)

Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia; CogState Ltd, Melbourne, Victoria, Australia.

Greg Savage (G)

Department of Biomedical Sciences, Faculty of Medicine and Health Science, Macquarie University, Sydney, New South Wales, Australia.

Christopher C Rowe (CC)

Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia; Department of Nuclear Medicine & Centre for PET, Austin Health, Heidelberg, Victoria, Australia.

Victor L Villemagne (VL)

Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia; Department of Nuclear Medicine & Centre for PET, Austin Health, Heidelberg, Victoria, Australia.

Belinda Brown (B)

Australian Alzheimer's Research Foundation, Ralph and Patricia Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia; Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia; Centre for Healthy Ageing, College of Science, Health, Engineering and Education (SHEE), Murdoch University, Murdoch, Western Australia, Australia.

Hamid R Sohrabi (HR)

Australian Alzheimer's Research Foundation, Ralph and Patricia Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Centre for Healthy Ageing, College of Science, Health, Engineering and Education (SHEE), Murdoch University, Murdoch, Western Australia, Australia; Department of Biomedical Sciences, Faculty of Medicine and Health Science, Macquarie University, Sydney, New South Wales, Australia. Electronic address: Hamid.Sohrabi@murdoch.edu.au.

Simon M Laws (SM)

Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Centre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia. Electronic address: s.laws@ecu.edu.au.

Ralph N Martins (RN)

Australian Alzheimer's Research Foundation, Ralph and Patricia Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Cooperative Research Centre for Mental Health, Carlton, Victoria, Australia; Department of Biomedical Sciences, Faculty of Medicine and Health Science, Macquarie University, Sydney, New South Wales, Australia. Electronic address: ralph.martins@mq.edu.au.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Androgen receptor CAG repeat length as a...
questionsmedicales.fr › Régions géographiques › Océanie › Australasie › Australie › Androgen receptor CAG repeat length as a...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Androgen receptor CAG repeat length as a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Androgen receptor CAG repeat length as a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs aux androgènes › Androgen receptor CAG repeat length as a...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la testostérone › Testostérone › Androgen receptor CAG repeat length as a...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Séquences répétées en tandem › Répétitions microsatellites › Répétitions de trinucléotides › Androgen receptor CAG repeat length as a...