Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4
Adolescent
Animals
Case-Control Studies
Child
Child, Preschool
Cohort Studies
Datasets as Topic
Diabetes Mellitus, Type 1
/ blood
Diarrhea
/ blood
Disease Models, Animal
Flow Cytometry
Forkhead Transcription Factors
/ deficiency
Genetic Diseases, X-Linked
/ blood
Humans
Immune System Diseases
/ blood
Infant
Male
Mice
Mice, Transgenic
Mutation
RNA-Seq
Single-Cell Analysis
T-Lymphocytes, Regulatory
/ immunology
Young Adult
Journal
Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
22
07
2020
accepted:
26
02
2021
pubmed:
10
4
2021
medline:
22
7
2021
entrez:
9
4
2021
Statut:
ppublish
Résumé
FOXP3 deficiency in mice and in patients with immune dysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome results in fatal autoimmunity by altering regulatory T (T
Identifiants
pubmed: 33833438
doi: 10.1038/s41590-021-00910-8
pii: 10.1038/s41590-021-00910-8
pmc: PMC8173714
mid: NIHMS1678410
doi:
Substances chimiques
FOXP3 protein, human
0
Forkhead Transcription Factors
0
Foxp3 protein, mouse
0
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
607-619Subventions
Organisme : NIAID NIH HHS
ID : R01 AI153174
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI128976
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI125603
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI150686
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI085090
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI116834
Pays : United States
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