A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood.
Adult
Cell Differentiation
/ immunology
Cells, Cultured
Female
Fetal Blood
/ cytology
Fetal Development
/ immunology
Humans
Intraepithelial Lymphocytes
/ immunology
Lymphocyte Activation
Male
RNA-Seq
Receptors, Antigen, T-Cell, gamma-delta
/ genetics
Single-Cell Analysis
T-Lymphocyte Subsets
/ immunology
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
23 04 2021
23 04 2021
Historique:
received:
28
09
2020
revised:
17
12
2020
accepted:
24
03
2021
entrez:
24
4
2021
pubmed:
25
4
2021
medline:
1
3
2022
Statut:
ppublish
Résumé
Accumulating evidence suggests that the mouse embryonic thymus produces distinct waves of innate effector γδ T cells. However, it is unclear whether this process occurs similarly in humans and whether it comprises a dedicated subset of innate-like type 3 effector γδ T cells. Here, we present a protocol for high-throughput sequencing of
Identifiants
pubmed: 33893173
pii: 6/58/eabf0125
doi: 10.1126/sciimmunol.abf0125
pii:
doi:
Substances chimiques
Receptors, Antigen, T-Cell, gamma-delta
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.