The IDIP framework for assessing protein function and its application to the prion protein.
distribution
epithelial-to-mesenchymal transition
function
inheritance
interaction
neural cell adhesion molecule
phenotype
polysialylation
prion protein
proteins
Journal
Biological reviews of the Cambridge Philosophical Society
ISSN: 1469-185X
Titre abrégé: Biol Rev Camb Philos Soc
Pays: England
ID NLM: 0414576
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
22
04
2021
received:
13
11
2020
accepted:
26
04
2021
pubmed:
8
5
2021
medline:
26
10
2021
entrez:
7
5
2021
Statut:
ppublish
Résumé
The quest to determine the function of a protein can represent a profound challenge. Although this task is the mandate of countless research groups, a general framework for how it can be approached is conspicuously lacking. Moreover, even expectations for when the function of a protein can be considered to be 'known' are not well defined. In this review, we begin by introducing concepts pertinent to the challenge of protein function assignments. We then propose a framework for inferring a protein's function from four data categories: 'inheritance', 'distribution', 'interactions' and 'phenotypes' (IDIP). We document that the functions of proteins emerge at the intersection of inferences drawn from these data categories and emphasise the benefit of considering them in an evolutionary context. We then apply this approach to the cellular prion protein (PrP
Substances chimiques
Prion Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1907-1932Informations de copyright
© 2021 The Authors. Biological Reviews published by John Wiley & Sons Ltd on behalf of Cambridge Philosophical Society.
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