Tracking the recruitment and evolution of snake toxins using the evolutionary context provided by the


Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
18 05 2021
Historique:
entrez: 11 5 2021
pubmed: 12 5 2021
medline: 15 12 2021
Statut: ppublish

Résumé

Venom is a key adaptive innovation in snakes, and how nonvenom genes were co-opted to become part of the toxin arsenal is a significant evolutionary question. While this process has been investigated through the phylogenetic reconstruction of toxin sequences, evidence provided by the genomic context of toxin genes remains less explored. To investigate the process of toxin recruitment, we sequenced the genome of

Identifiants

pubmed: 33972420
pii: 2015159118
doi: 10.1073/pnas.2015159118
pmc: PMC8157943
pii:
doi:

Substances chimiques

Crotalid Venoms 0
Proteome 0
Snake Venoms 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Déclaration de conflit d'intérêts

The authors declare no competing interest.

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Auteurs

Diego Dantas Almeida (DD)

Laboratório de Toxinologia Aplicada, Center of Toxins, Immune-Response and Cell Signaling, Instituto Butantan, São Paulo 05503-900, Brazil.

Vincent Louis Viala (VL)

Laboratório de Toxinologia Aplicada, Center of Toxins, Immune-Response and Cell Signaling, Instituto Butantan, São Paulo 05503-900, Brazil.

Pedro Gabriel Nachtigall (PG)

Laboratório de Toxinologia Aplicada, Center of Toxins, Immune-Response and Cell Signaling, Instituto Butantan, São Paulo 05503-900, Brazil.

Michael Broe (M)

Department of Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH 43210.

H Lisle Gibbs (HL)

Department of Evolution, Ecology and Organismal Biology, The Ohio State University, Columbus, OH 43210.

Solange Maria de Toledo Serrano (SMT)

Laboratório de Toxinologia Aplicada, Center of Toxins, Immune-Response and Cell Signaling, Instituto Butantan, São Paulo 05503-900, Brazil.

Ana Maria Moura-da-Silva (AM)

Laboratório de Imunopatologia, Instituto Butantan, São Paulo 05503-900, Brazil.
Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas (UEA), Manaus 69040-000, Brazil.

Paulo Lee Ho (PL)

Serviço de Bacteriologia, Divisão BioIndustrial, Instituto Butantan, São Paulo 05503-900, Brazil.

Milton Yutaka Nishiyama-Jr (MY)

Laboratório de Toxinologia Aplicada, Center of Toxins, Immune-Response and Cell Signaling, Instituto Butantan, São Paulo 05503-900, Brazil.

Inácio L M Junqueira-de-Azevedo (ILM)

Laboratório de Toxinologia Aplicada, Center of Toxins, Immune-Response and Cell Signaling, Instituto Butantan, São Paulo 05503-900, Brazil; inacio.azevedo@butantan.gov.br.

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Classifications MeSH